2010 Fiscal Year Final Research Report
Search for gelsedine-type Gelsemium alkaloids to develop new antitumor lead compounds
| Project/Area Number |
19510211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Chiba University |
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Principal Investigator |
KITAJIMA Mariko Chiba University, 大学院・薬学研究院, 准教授 (60195261)
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| Co-Investigator(Kenkyū-buntansha) |
KOGURE Noriyuki 千葉大学, 大学院・薬学研究院, 助教 (80396689)
NAKAMURA Tomonori 群馬大学, 大学院・医学系研究科, 准教授 (30251151)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 天然物化学 / アルカロイド / 構造解析 / 化学変換 / 細胞毒性 |
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| Research Abstract |
To discover and develop lead compound for new antitumor agent origenated from plant alkaloids, chemical investigation and biological evaluation of Gelsemium alkaloids were carried out. As a result, several new alkaloids having novel structures were isolated from Gelsemium plants. Chemical transformation of a humantenine-type alkaloid to gelsedine-type alkaloids was accomplished. Yohimbane-type alkaloids showed the cytotoxic effects on some human tumor cells.
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