2009 Fiscal Year Final Research Report
Synthesis of glutamine transporter inhibitors regulating amino acids concentrations in neurotransmission system
| Project/Area Number |
19510228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Suntory Institute for Bioorganic Research |
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Principal Investigator |
SHIMAMOTO Keiko Suntory Institute for Bioorganic Research, 研究員 (70235638)
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| Project Period (FY) |
2007 – 2009
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| Keywords | グルタミン / トランスポーター / 阻害剤 / グリア細胞 / 立体配座固定 / グルタミン酸 |
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| Research Abstract |
Extracellular concentrations of amino acids and sugars are regulated by transporters. In order to elucidate physiological roles in neurotransmission system and substrate recognition mechanisms of these transporters, we synthesized selective inhibitors for neutral amino acid transporter (ASCT2) and glutamate-cyctine exchanger (xCT).
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Research Products
(7 results)
