2009 Fiscal Year Final Research Report
Effects of probiotics on human intestinal absorption and metabolism of drugs.
| Project/Area Number |
19590123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Keio University (2008-2009)
Kyoritsu University of Pharmacy (2007) |
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Principal Investigator |
SHIMIZU Mikiko Keio University, 薬学部, 講師 (90396391)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIGUCHI Masayuki 慶應義塾大学, 薬学部, 准教授 (10271355)
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| Research Collaborator |
SUGITA Takashi 明治薬科大学, 薬学部, 准教授 (10312076)
TAKEUCHI Osamu (社)北里研究所, 北里研究所病院, 研究員 (00249997)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 消化管 / 小腸 / 薬物動態 / プロバイオティクス / 薬物代謝酵素 / 薬物輸送担体 / 脂質異常症 / メタアナリシス |
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| Research Abstract |
In experiments using human intestinal epithelial-like Caco-2 cells and rats, we clarified that probiotics containing Lactobacillus casei affect the pharmacokinetics of coadministered drugs, which are metabolized by CYP3A4, subjected to the conjugation reaction, or transported by BCRP in the small intestine. In a meta-analysis, we also clarified that probiotic supplementation may lead to reductions in risk factors for cardiovascular disease and could be useful in the primary prevention of hyperlipidemia.
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