Basic studies on the treatment and prevention of hepatocellular carcinoma with interferon

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kurume University
• Principal Investigator: YANO Hirohisa Kurume University, 医学部, 教授 (40220206)
• Co-Investigator(Kenkyū-buntansha): OGASAWARA Sachiko 久留米大学, 医学部, 講師 (40258405) ; AKIBA Jun 久留米大学, 医学部, 講師 (00341305)
• Project Period (FY): 2007 – 2009
• Keywords: 腫瘍 / サイトカイン / インターフェロン / アポトーシス / 阻害剤 / 分子標的薬剤

Research Abstract

To induce efficient anti-proliferative effect of interferon (IFN) on hepatocellular carcinoma cells, we performed the following investigation : 1) combination of other drugs with IFN, 2) application of new drug delivery system, and 3) determination and functional analysis of the molecules closely related with IFN-mediated apoptosis induction. As a result, combination of IFN with anti-angiogenesis drug was effective to a certain extent. New drug delivery system worked to some extent and may be more effective after some improvement. XAF-1 and TRAIL were closely related with the induction of apoptosis and the regulation of XAF-1 and TRAIL will modify the anti-proliferative effect of IFN.

Research Products

• [Journal Article] Inhibitory function of interferon on hepatocarcinogenesis (2008)
  • Author(s): Yano H.
  • Journal Title: Oncology 75 Pages: 22-29
  • Peer Reviewed
• [Journal Article] 肝癌の発生・進展とインターフェロンによる制御 (2008)
  • Author(s): 矢野博久
  • Journal Title: J Microwave Surg 26 Pages: 21-26
• [Journal Article] Growth inhibitory effects of pegylated IFN-a2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo. (2008)
  • Author(s): Moriya F., Ogasawara S., Basaki Y., Akiba J., Kojiro S., Fukahori S., Ishizaki H., Nishida N., Matsuoka K., Kojiro M., Kuwano M., Yano H.
  • Journal Title: Int J Oncol 33 Pages: 647-655
  • Peer Reviewed
• [Journal Article] X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expression and their relationship to apoptosis in human hepatocellular carcinoma and non-carcinomatous liver tissues Oncology Reports (2007)
  • Author(s): Sakemi, R, Yano H, Ogasawara S, Akiba J, Nakashima O, Fukahori S, Michio S, Kojiro M.
  • Journal Title: 18 Pages: 65-70
  • Peer Reviewed
• [Journal Article] Growth inhibitory effects of IFN-βon human liver cancer cells in vitro and in vivo Journal of Interferon & Cytokine Research (2007)
  • Author(s): Ogasawara S, Yano H, Momosaki S, Akiba J, Nishida N, Kojiro S, Moriya F, Ishizaki H, Kuratomi K, Kojiro M.
  • Journal Title: 27 Pages: 507-516
• [Journal Article] Alteration of dihydropyrimidine dehydrogenase expression by IFN-βaffects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells Mol Cancer Ther (2007)
  • Author(s): Oie S, Ono M, Fukushima H, Hosoi F, Yano H, Maruyama Y, Kojiro M, Terada T, Hirano K, Kuwano M, Yamada Y.
  • Journal Title: 6 Pages: 2310-8
  • Peer Reviewed
• [Presentation] シグナル伝達分子阻害剤単独あるいはインターフェロンとの併用による肝癌細胞の増殖抑制効果の検討 (2009)
  • Author(s): 小笠原幸子, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Expression of RecQL1 helicase in hepatocellular carcinoma. (2009)
  • Author(s): Ogasawara S., et al.
  • Organizer: Annual Meeting of International Liver cancer Association.
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-09-05
• [Presentation] Quercetin suppresses the proliferation of liver cancer cell lines in vitro. (2009)
  • Author(s): Hisaka T., et al.
  • Organizer: Annual Meeting of International Liver cancer Association.
  • Place of Presentation: Milan, Italy.
  • Year and Date: 2009-09-05
• [Presentation] 肝細胞癌におけるRecQL1ヘリカーゼ発現の臨床病理学的検討 (2009)
  • Author(s): 小笠原幸子, 他
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Presentation] Analyses of the expression of interferon-mediated apoptosis-related molecules in human liver cancer cell line (2008)
  • Author(s): Yano H., et al.
  • Organizer: Annual Meeting of International Liver cancer Association
  • Place of Presentation: Chicago, USA.
  • Year and Date: 2008-09-04
• [Presentation] ペグインターフェロン-α2bにより肝細胞癌株に誘導されるアポトーシス及び細胞周期関連遺伝子の変化に関する研究 (2008)
  • Author(s): 小笠原幸子, 他
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 松山
  • Year and Date: 2008-06-06