2009 Fiscal Year Final Research Report
Modified mycolic acids in Mycobacterium tuberculosis regulate the host immune responses
| Project/Area Number |
19590453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka City University |
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Principal Investigator |
FUJIWARA Nagatoshi Osaka City University, 大学院・医学研究科, 講師 (80326256)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Ikuya 日本ビーシージー製造株式会社, 中央研究所, 顧問 (60047008)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 感染免疫 / 脂質分子 / 宿主応答 / 結核菌 / ミコール酸 |
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| Research Abstract |
Mycolic acid is a characteristic cell wall component expressed in acid-fast bacteria containing Mycobacterium tuberculosis. The heterogeneity of mycolic acid subclasses (α, methoxy, keto, dicarboxy, epoxy, etc), unsaturations (monoene, diene, cyclopropane), and geometrical isomers (cis, trans) effected to cord forming, acid-fastness, and host immune responses to Mycobacteria. The modifications of mycolic acids play an important role in their virulence and pathogenecity.
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Research Products
(29 results)
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[Journal Article] Mycobacterium kyorinense sp. nov., a novel slowly growing Mycobacterium sp. related to Mycobacterium celatum isolated from human clinical specimens.2009
Author(s)
M. Okazaki, K. Ohkusu, H. Hata, H. Ohnishi, K. Sugawara, C. Kawamura, N. Fujiwara, S. Matsumoto, Y. Nishiuchi, K. Toyoda, H. Saito, S. Yonetani, Y. Fukugawa, M. Yamamoto, H. Wada, A. Sejimo, A. Ebina, H. Goto, T. Ezaki, T. Watanabe
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Journal Title
IJSEM 59
Pages: 1336-1341
Peer Reviewed
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[Journal Article] Comparable Studies of Immunostimulating Activities In Vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) Sub-strains.2009
Author(s)
D. Hayashi, T. Takii, N. Fujiwara, Y. Fujita, I. Yano, S. Yamamoto, M. Kondo, E. Yasuda, E. Inagaki, K. Kanai, A. Fujiwara, A. Kawarazaki, T. Chiba, K. Onozaki
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Journal Title
FEMS Immunol. Med. Microbiol 56
Pages: 116-128
Peer Reviewed
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[Journal Article] Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare.2008
Author(s)
N. Fujiwara, N. Nakata, T. Naka, I. Yano, M. Doe, D. Chatterjee, M. McNeil, P.J. Brennan, K. Kobayashi, M. Makino, S. Matsumoto, H. Ogura, S. Maeda
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Journal Title
J. Bacteriol 190
Pages: 3613-3621
Peer Reviewed
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[Journal Article] Control of cell wall assembly by a histone-like protein in mycobacteria.2007
Author(s)
T. Katsube, S. Matsumoto, M. Takatsuka, M. Okuyama, Y. Ozeki, M. Naito, Y. Nishiuchi, N. Fujiwara, M. Yoshimura, T. Tsuboi, M. Torii, N. Oshitani, T. Arakawa, K. Kobayashi
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Journal Title
J. Bacteriol 189
Pages: 8241-8249
Peer Reviewed
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