• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

The diagnosis of acute myeloid leukemia based on the new WHO classification in the multicenter study.

Research Project

  • PDF
Project/Area Number 19590565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionUniversity of the Ryukyus

Principal Investigator

KURIYAMA Kazutaka  University of the Ryukyus, 医学部, 教授 (90128174)

Co-Investigator(Renkei-kenkyūsha) MIYAZAKI Yasushi  長崎大学, 医学部・歯学部附属病院, 講師 (40304943)
HATA Tomoko  長崎大学, 医学部・歯学部附属病院, 助教 (10346968)
Project Period (FY) 2007 – 2009
Keywords急性骨髄性白血病 / WHO分類 / 中央診断システム / 染色体異常 / 遺伝子異常 / 予後因子
Research Abstract

We diagnosed the patients registered with AML treatment protocol (AML-97) of Japan Adult Leukemia Study Group according to WHO classification in 2001.628 patients registered with the AML-97 protocol were diagnosed as AML with recurrent genetic abonrmalities (171patients;26.8%), AML with multilineage dysplasia (133;20.8%), AML not otherwise categorized (331;51.9%) or acute leukemia of ambiguous lineage (3;0.5%), respectively. These diagnoses were not so different from the diagnoses by the revised WHO classification in 2008, except that 32 patients having 11q23 abnormalities decreased to 9 patients because only t(9;11) was taken up in 2008.

  • Research Products

    (13 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Book (3 results)

  • [Journal Article] Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size: a report by the Nagasaki CML Study Group2009

    • Author(s)
      Sakai M、Miyazaki Y、Hata T(5番目)、Kuriyama K(40番目), 他37名
    • Journal Title

      International Journal of Hematology VOL.89

      Pages: 319-325

    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia2009

    • Author(s)
      Ishikawa Y、Miyazaki Y( 5番目)、Kuriyama K(6番目), 他5名
    • Journal Title

      European Journal of Haematology VOL.83

      Pages: 90-98

    • Peer Reviewed
  • [Journal Article] 造血器腫瘍の改訂WHO(2008)分類2009

    • Author(s)
      栗山一孝
    • Journal Title

      日本検査血液学会誌 VOL.10

      Pages: 383-392

    • Peer Reviewed
  • [Journal Article] Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol2008

    • Author(s)
      Wakui M、Kuriyama K、Miyazaki Y、Hata T, 他7名
    • Journal Title

      International Journal of Hematology VOL.87

      Pages: 144-151

    • Peer Reviewed
  • [Journal Article] Expression of myeloperoxidase enhances the chemosensitivity of leukemia cells through the generation of reactive oxygen species and the nitration of protein2008

    • Author(s)
      Sawayama Y、Miyazaki Y、Hata T(9番目)、Kuriyama K(15番目), 他12名
    • Journal Title

      Leukemia VOL.22

      Pages: 956-964

    • Peer Reviewed
  • [Presentation] 造血器腫瘍の改訂WHO(2008)分類2009

    • Author(s)
      栗山一孝
    • Organizer
      第10回日本検査血液学会学術集会
    • Place of Presentation
      甲府市
    • Year and Date
      2009-07-04
  • [Presentation] he genotype consisting of complex karyotype and TP53 gene mutation is specific to acute myeloid leukemia with multilineage dysplasia2008

    • Author(s)
      Ishikawa Y
    • Organizer
      49th American Society of Hematology
    • Place of Presentation
      San Francisco(USA)
    • Year and Date
      2008-12-07
  • [Presentation] Expression of the 67-kDa Laminin Receptor Is Associated with Increased AML Cells though the Enhanced GM-CSF/Stat5 Signaling2007

    • Author(s)
      Ando K
    • Organizer
      48th American Society of Hematology
    • Place of Presentation
      Orland(USA)
    • Year and Date
      2007-12-10
  • [Presentation] Comprehensive Analysis of Genetic Alterations in Acute Myeloid Leukemia According to the WHO Classification2007

    • Author(s)
      Ishikawa Y
    • Organizer
      48th American Society of Hematology
    • Place of Presentation
      Orland(USA)
    • Year and Date
      2007-12-08
  • [Presentation] 造血器腫瘍の総合的細胞診断に向けて「総合診断」(大会長シンポジウム)2007

    • Author(s)
      栗山一孝
    • Organizer
      第8回日本検査血液学会学術集会
    • Place of Presentation
      フェニックス・プラザ(福井市)
    • Year and Date
      2007-07-21
  • [Book] 改訂第4版造血器腫瘍アトラス形態、免疫、染色体と遺伝子2009

    • Author(s)
      栗山一孝
    • Total Pages
      263-267
    • Publisher
      日本医事新報社
  • [Book] WHO分類第4版よる白血病・リンパ系腫瘍の病態学2009

    • Author(s)
      栗山一孝
    • Total Pages
      71-86
    • Publisher
      中外医学社
  • [Book] 講義録血液・造血器2008

    • Author(s)
      栗山一孝
    • Total Pages
      72-76
    • Publisher
      メジカルビュー社

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi