2009 Fiscal Year Final Research Report
Exhaled breath condensate analysis in difficult asthma
| Project/Area Number |
19591175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MATSUNAGA Kazuto Wakayama Medical University, 医学部, 講師 (20347602)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 気管支喘息 / 呼気凝縮液 / 気道炎症 / ステロイド / 炎症関連物質 / 難治性喘息 |
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| Research Abstract |
Airway inflammation in asthma is associated with airway obstruction and airway hyperresponsiveness. It is generally assumed that steroid therapy reduces airway inflammation. However, not all individuals respond similarly to steroid like as difficult asthma. Exhaled breath condensate (EBC) analysis is a noninvasive method for assessing inflammatory molecules in the airways. This study demonstrated that increased IL-4 and RANTES levels as well as decreased IP-10 levels at baseline were correlated with an improvement in airway obstruction. EBC measurements of IL-4, RANTES and IP-10 might be useful for predicting the steroid-resistant asthma.
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Research Products
(34 results)
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[Journal Article] Peak expiratory flow variability adjusted by forced expiratory volume in one second is a good index for airway responsiveness in asthmatics.2008
Author(s)
K. Matsunaga, M. Kanda, A. Hayata, S. Yanagisawa, T. Ichikawa, K. Ak amatsu, A. Koarai, T. Hirano, H. Su giura, Y. Minakata, M. Ichinose
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Journal Title
Intern Med 47
Pages: 1107-12
Peer Reviewed
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[Journal Article] The influence of free 3-Nitrotyrosine and saliva on the quantitative analysis of protein-bound 3-Nitrotyrosine in sputum.2007
Author(s)
Ueshima K, Minakata Y, Sugiura H, Yanagisawa S, Ichikawa T, Akainatsu K, Hirano T, Nakanishi M, Matsunags. K, Yamagata T, Ichinose M
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Journal Title
Analytical chemistry insights 1
Pages: 1-7
Peer Reviewed
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