2009 Fiscal Year Final Research Report
Decipering the resistome of a pathogenic actinomycete Nocardia farcinica
| Project/Area Number |
19591196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ISHIKAWA Jun National Institute of Infectious Diseases, 生物活性物質部, 室長 (40202957)
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| Co-Investigator(Kenkyū-buntansha) |
ISHINO Keiko 国立感染症研究所, 生物活性物質部, 主任研究官 (50332359)
HOSHINO Yasutaka 国立感染症研究所, 生物活性物質部, 主任研究官 (40399457)
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| Research Collaborator |
FUJII Shoko 東邦大学, 大学院・理学研究科
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| Project Period (FY) |
2007 – 2009
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| Keywords | 薬剤耐性 / 抗生物質 / 感染症 / ノカルジア / レジストーム |
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| Research Abstract |
Nocardia is a species of soil actinomycetes and an opportunistic pathogen caused nocadiosis on human or animal. Treatment of nocardiosis is difficult because of the multi-drug resistant profile of Nocardia. However, the mechanisms of the resistance have not been studied with a few exceptions. We demonstrated the resistance mechanisms for rifampicin, aminoglycosides, and chloramphenicol as part of deciphering all the resistance mechanisms (resistome) of N.farcinica.
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[Journal Article] Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance.2010
Author(s)
Hoshino, Y., Fujii, S., Shinonaga, H., Arai, K., Saito, F., Fukai, T., Satoh, H., Miyazaki, Y., Ishikawa, J.
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Journal Title
Journal of Antibiotics 63
Pages: 23-28
Peer Reviewed
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