2009 Fiscal Year Final Research Report
Neurobiological and behavioral consequences of exposure to childhood traumatic stress and preliminary evidence for sensitive periods in the effect of childhood abuse on regional brain development.
| Project/Area Number |
19591210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kumamoto University |
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Principal Investigator |
TOMODA Akemi Kumamoto University, 大学院・生命科学研究部, 准教授 (80244135)
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| Co-Investigator(Renkei-kenkyūsha) |
MIIKE Teruhisa 熊本大学, 大学院・生命科学研究部, 名誉教授 (90040617)
TAKANO Miyuki 熊本大学, 大学院・生命科学研究部, 臨床心理士 (40433031)
JODOI Takako 熊本大学, 医学部附属病院, 助教 (90363522)
KAWATANI Junko 熊本大学, 大学院・生命科学研究部, 社会人大学院生 (30423669)
SHIRAISHI Seiji 熊本大学, 医学部附属病院, 医員 (60448529)
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| Research Collaborator |
TEICHER M.H. Department of Psychiatry, Harvard Medical School
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| Project Period (FY) |
2007 – 2009
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| Keywords | 社会医学 / 脳・神経 / 臨床 / ストレス / 小児発達学 |
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| Research Abstract |
Brain development is largely guided by genetic factors, but the final form is sculpted by environmental factors and early experience. Exposure to traumatic events such as childhood abuse and neglect, have been associated with alterations in the size or functional activity of a variety of brain regions. We have conducted a voxel-based morphometry (VBM) study in young adults with histories of exposure to repeated episodes of childhood sexual abuse and found that the most significant differences were bilateral reductions in gray matter volume (GMV) in the visual cortex (BA 17, 18). Similarly, we conducted a VBM analysis in young adults exposed to parental verbal aggression, and observed an increase in the left superior temporal gyrus (BA 22). These findings fit with an emerging hypothesis that exposure to early adversity may be associated with alterations in sensory systems that process and convey the adverse sensory experience. Severe abuse during childhood can cause abnormal brain development and have a negative impact later in life.
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[Journal Article] Effort-reward imbalance for learning is associated with fatigue in school children2010
Author(s)
Fukuda S., Yamano E., Jodoi T., Mizuno K., Tanaka M., Kawatani J., Takano M., Tomoda A., Imai-Matsumura K, Miike T, Watanabe Y
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Journal Title
Behavioral Medicine 36(2)
Pages: 53-62
Peer Reviewed
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[Book] Ontogenetic perspectives on the neurobiological basis of psychopathology following abuse and neglect2010
Author(s)
Bernadini S., Teicher M. H*., Rabi K., Sheu Y., Andersen S. L., Anderson C. M., Choi J., Tomoda A
Publisher
The Interaction of Caregiving, Culture, and Developmental Psychobiology, Cambridge University Press
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