2009 Fiscal Year Final Research Report
Studies to establish the mechanisms of neonatal chronic lung disease due to intrauterine inflammation with rats
| Project/Area Number |
19591275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
CHO Kazutoshi Hokkaido University, 病院, 准教授 (10312365)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUSHIMA Masato 北海道大学, 病院, 助教 (40455671)
SATOMI Tatsuo 北海道大学, 病院, 医員 (00455669)
WATANABE Maiko 北海道大学, 病院, 医員 (30455670)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 新生児 / 慢性肺疾患 / 子宮内炎症 / エンドトキシン / ステロイド |
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| Research Abstract |
Postnatal administration of steroids did not induce a significant change in the pulmonary structure with respect to the alveolar surface density , numerical density of alveoli and the average of alveolar radius in the rats treated with antenatal lipopolysaccharide. These results suggest that postnatal steroids do not exert favorable effects on chronic lung disease induced by intrauterine inflammation.
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