2009 Fiscal Year Final Research Report
Diagnostic performance and prognostic value of ^<18>F-FAMT PET in non-small cell lung cancer
| Project/Area Number |
19591400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
ORIUCHI Noboru Gunma University, 大学院・医学系研究科, 准教授 (40292586)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Norifumi 群馬大学, 医学部, 准教授 (10292583)
IIDA Yasuhiko 群馬大学, 大学院・医学系研究科, 客員教授 (60252425)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ポジトロンCT / 分子標的治療 / 肺癌 / ^<18>F-FDG / ^<18>F-FAMT / LAT1 |
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| Research Abstract |
Diagnostic performance and value of ^<18>F-FAMT PET was examined to verify clinical implication in patients with non-small cell lung cancer (NSCLC). Specificity of ^<18>F-FAMT PET was superior to ^<18>F-FDG PET. The uptake of ^<18>F-FAMT was correlated with LAT1 expression as well as cellular proliferation and VEGF expression. Patients with positive LAT1 had significantly shorter 5-year survival as compared with negative LAT1. LAT1, as well as pathological stage and CD98 expression, was an independent prognostic factor, indicating diagnostic and prognostic value of ^18<F>-FAMT PET in NSCLC.
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[Journal Article] CD98 Expression is Associated with Poor Prognosis in Resected Non-small Cell Lung Cancer with Lymph Node Metastases2009
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Kawashima O, Kamide S, Ishizuka T, Kanai Y, Nakajima T, Mori M.
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Journal Title
A Surg Oncol 16
Pages: 3473-3481
Peer Reviewed
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[Journal Article] Prognostic significance of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma2009
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Nakajima T, Mori M.
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Journal Title
Lung Cancer 66
Pages: 120-6
Peer Reviewed
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[Journal Article] Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung2009
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Mori M.
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Journal Title
Cancer Sci 100
Pages: 249-254
Peer Reviewed
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[Journal Article] Clinical significance of performing ^<18>F-FDG PET on patients with gastrointestinal stromal tumors : a summary of a Japanese multicenter study2009
Author(s)
Kaneta T, Takahashi S, Fukuda H, Arisaka Y, Oriuchi N, Hayashi T, Fujii H, Terauchi T, Tateishi U, Kubota K, Hara T, Nakamoto Y, Kitajima K, Murakami K.
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Journal Title
Ann Nucl Med 23
Pages: 459-64
Peer Reviewed
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[Journal Article] L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas2009
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Mori M.
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Journal Title
J Surg Oncol 99
Pages: 433-8
Peer Reviewed
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