2009 Fiscal Year Final Research Report
Molecular imaging using F-18 FLT PET in patients with lung cancer
| Project/Area Number |
19591421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
YAMAMOTO Yuka Kagawa University, 医学部附属病院, 講師 (30335872)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Yoshihiro 香川大学, 医学部, 教授 (50263900)
HABA Reiji 香川大学, 医学部附属病院, 准教授 (90304584)
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| Project Period (FY) |
2007 – 2009
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| Keywords | F-18 FDG / F-18 FLT / PET検査 / 肺癌 / 分子イメージング |
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| Research Abstract |
The nucleoside analogue FLT with PET has been introduced for imaging cell proliferation. The purpose of this study is to assess the clinical value of F-18 FLT PET in patients who suspected lung tumors on CT scan or chest X-ray, and to compare the uptake of F-18 FLT and F-18 FDG. Our experience demonstrates that F-18 FDG PET shows higher sensitivity than F-18 FLT PET for depiction of lung cancer, however, F-18 FLT PET shows higher specificity than F-18 FDG PET. F-18 FLT PET shows better specificity for lymph node staging than F-18 FDG PET. F-18 FLT PET is not sensitive than F-18 FDG PET for detection of distant metastasis. Follow-up F-18 FLT PET may be helpful for monitoring therapeutic assessment.
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