Individualized radiotherapy with molecular imaging of tumor

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591468
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: OHNO Tatsuya Gunma University, 重粒子線医学推進機構, 准教授 (10344061)
• Co-Investigator(Kenkyū-buntansha): KATO Shingo 放射線医学総合研究所, 重粒子医科学センター, 研究員 (00370875) ; YOSHIKAWA Kyosan 放射線医学総合研究所, 重粒子医科学センター, 研究員 (00204793) ; IWAKAWA Mayumi 放射線医学総合研究所, 重粒子医科学センター, 研究員 (30231723)
• Project Period (FY): 2007 – 2009
• Keywords: 分子イメージング / 悪性腫瘍 / 放射線治療

Research Abstract

In the present study, we evaluated (1) the correlation between radiosensitivities of murine tumor and accumulation of ^<62>Cu-ATSM, (2) the correlation of MetAP2 overexpression and Metionine PET in uterine cervical cancer patients, (3) Simulation model of ^<62>Cu-ATSM PET based treatment planning for hypoxic tumors, (4) detection of biomarker by using microarray analysis in relation to prognosis of cervical cancer patients. The results indicated radiosensitivity correlated with the accumulation of ^<62>Cu-ATSM in the tumor, and molecular imaging is highly effective in the treatment with carbon ion radiotherapy.

Research Products

• [Journal Article] CT-based 3Ddose-volume parameter of the rectum and late rectal complication in patients with cervical cancer treated with high-dose-rate intracavitary brachytherapy (2010)
  • Author(s): Kato S, Tran DN, Ohno T, Nakano T, Kiyohara H, Ohkubo Y, Kamada T.
  • Journal Title: J Radiat Res (Tokyo) 51(2) Pages: 215-21
  • Peer Reviewed
• [Journal Article] Current advancement in radiation therapy for uterine cervical cancer (2010)
  • Author(s): Nakano T, Ohno T, Ishikawa H, Suzuki Y, Takahashi T.
  • Journal Title: J Radiat Res (Tokyo) 51(1) Pages: 1-8
  • Peer Reviewed
• [Journal Article] A Consensus-based Guideline Defining the Clinical Target Volume for Pelvic Lymph Nodes in External Beam Radiotherapy for Uterine Cervical Cancer (2010)
  • Author(s): Toita T, Ohno T, Kaneyasu Y, Uno T, Yoshimura R, Kodaira T, Furutani K, Kasuya G, Ishikura S, Kamura T, Hiraoka M.
  • Journal Title: Jpn J Clin Oncol. (in press)
  • Peer Reviewed
• [Journal Article] Multi-Institutional Phase II Clinical Study of Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer in East and Southeast Asia (2009)
  • Author(s): Kato S, Ohno T, Thephamongkhol K, Chansilpa Y, Yuxing Y, Devi CR, Bustam AZ, Calaguas MJ, de Los Reyes RH, Cho CK, Dung TA, Supriana N, Mizuno H, Nakano T, Tsujii H.
  • Journal Title: Int J Radiat Oncol Biol Phys. (in press)
  • Peer Reviewed
• [Journal Article] Psychological distress and quality of life in cervical cancer survivors after radiotherapy : do treatment modalities, disease stage, and self-esteem influence outcomes? (2009)
  • Author(s): Kobayashi M, Ohno T, Noguchi W, Matsuda A, Matsushima E, Kato S, Tsujii H.
  • Journal Title: Int J Gynecol Cancer 19(7) Pages: 1264-8
  • Peer Reviewed
• [Journal Article] Quality assurance in the prospective multi-institutional trial on definitive radiotherapy using high-dose-rate intracavitary brachytherapy for uterine cervical cancer : the individual case review (2009)
  • Author(s): Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kodaira T, Kazumoto T, Kataoka M, Shikama N, Kenjo M, Teshima T, Kagami Y.
  • Journal Title: Jpn J Clin Oncol. 39(12) Pages: 813-9
  • Peer Reviewed
• [Journal Article] Villin1, a novel diagnostic marker for cervical adenocarcinoma (2009)
  • Author(s): Nakamura E, Iwakawa M, Furuta R, Ohno T, Satoh T, Nakawatari M, Ishikawa KI, Imadome K, Michikawa Y, Tamaki T, Kato S, Kitagawa T, Imai T.
  • Journal Title: Cancer Biol Ther. 8(12)
  • Peer Reviewed
• [Journal Article] Application of carbon-ion beams or gamma-rays on primary tumors does not change the expression profiles of metastatic tumors in an in vivo murine model (2009)
  • Author(s): Tamaki T, Iwakawa M, Ohno T, Imadome K, Nakawatari M, Sakai M, Tsujii H, Nakano T, Imai T.
  • Journal Title: Int J Radiat Oncol Biol Phys. 74(1) Pages: 210-8
  • Peer Reviewed
• [Journal Article] Prognostic impact of mitotic index of proliferating cell populations in cervical cancer patients treated with carbon ion beam (2009)
  • Author(s): Suzuki Y, Oka K, Ohno T, Kato S, Tsujii H, Nakano T.
  • Journal Title: Cancer 115(9) Pages: 1875-82
• [Journal Article] Prediction of early response to radiotherapy of uterine carcinoma with dynamic contrast-enhanced MR imaging using pixel analysis of MR perfusion imaging (2009)
  • Author(s): Takayama Y, Ohno T, Kishimoto R, Kato S, Yoneyama R, Kandatsu S, Tsujii H, Obata T.
  • Journal Title: Magn Reson Imaging 27(3) Pages: 370-6
  • Peer Reviewed
• [Journal Article] Comparison of the radiobiological effect of carbon ion beam therapy and conventional radiation therapy on cervical cancer (2008)
  • Author(s): Suzuki Y, Nakano T, Ohno T, Oka K.
  • Journal Title: J Radiat Res (Tokyo) 49(5) Pages: 473-9
  • Peer Reviewed
• [Journal Article] Japan Radiation Oncology Study Group (2008)
  • Author(s): Sakata K, Sakurai H, Suzuki Y, Kato S, Ohno T, Toita T, Kataoka M, Tanaka E, Kaneyasu Y, Uno T, Harima Y, Nakano T
  • Journal Title: Results of concomitant chemoradiation for cervical cancer using high dose rate intracavitary brachytherapy: study of JROSG (Japan Radiation Oncology Study Group).Acta Oncol. 47(3) Pages: 434-41
  • Peer Reviewed
• [Journal Article] p73 protein expression correlates with radiation-induced apoptosis in the lack of p53 response to radiation therapy for cervical cancer (2008)
  • Author(s): Wakatsuki M, Ohno T, Iwakawa M, Ishikawa H, Noda S, Ohta T, Kato S, Tsujii H, Imai T, Nakano T.
  • Journal Title: Int J Radiat Oncol Biol Phys. 70(4) Pages: 1189-94
  • Peer Reviewed
• [Journal Article] Accelerated hyperfractionated radiotherapy for cervical cancer : multi-institutional prospective study of forum for nuclear cooperation in Asia among eight Asian countries (2008)
  • Author(s): Ohno T, Nakano T, Kato S, Koo CC, Chansilpa Y, Pattaranutaporn P, Calaguas MJ, de Los Reyes RH, Zhou B, Zhou J, Susworo R, Supriana N, Dung TA, Ismail F, Sato S, Suto H, Kutsutani-Nakamura Y, Tsujii H.
  • Journal Title: Int J Radiat Oncol Biol Phys. 70(5) Pages: 1522-9
  • Peer Reviewed
• [Journal Article] Chemoradiation-induced expression of fibroblast growth factor-2 and laminin in patients with cervical cancer (2007)
  • Author(s): Nakawatari M, Iwakawa M, Ohno T, Kato S, Tamaki T, Imadome K, Sakai M, Tsujii H, Imai T.
  • Journal Title: Cancer Biol Ther. 6(11) Pages: 1780-6
  • Peer Reviewed
• [Journal Article] Long-term survival and risk of second cancers after radiotherapy for cervical cancer (2007)
  • Author(s): Ohno T, Kato S, Sato S, Fukuhisa K, Nakano T, Tsujii H, Arai T.
  • Journal Title: Int J Radiat Oncol Biol Phys. 69(3) Pages: 740-5
  • Peer Reviewed
• [Journal Article] The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer (2007)
  • Author(s): Iwakawa M, Ohno T, Imadome K, Nakawatari M, Ishikawa K, Sakai M, Kato S, Ishikawa H, Tsujii H, Imai T.
  • Journal Title: Cancer Biol Ther. 6(6) Pages: 905-11
  • Peer Reviewed
• [Journal Article] A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries (2007)
  • Author(s): Nakano T, Kato S, Cao J, Zhou J, Susworo R, Supriana N, Sato S, Ohno T, Suto H, Nakamura Y, Cho CK, Ismail FB, Calaguas MJ, de Los Reyes RH, Chansilpa Y, Thephamongkhol K, Duc NB, Dung TA, Tsujii H.
  • Journal Title: Radiother Oncol. 84(3) Pages: 314-9
  • Peer Reviewed
• [Journal Article] Clinical Results of Carbon Ion Radiotherapy (2007)
  • Author(s): Tsujii H, Mizoe J, Kamada T, Baba M, Tsuji H, Kato H, Kato S, Yamada S, Yasuda S, Ohno T, Yanagi T, Imai R, Kagei K, Kato H, Hara R, Hasegawa A, Nakajima M, Sugane N, Tamaki N, Takagi R, Kandatsu S, Yoshikawa K, Kishimoto R, Miyamoto T.
  • Journal Title: NIRS. J Radiat Res (Tokyo) 48 Pages: A1-A13
  • Peer Reviewed
• [Journal Article] Late rectal complications evaluated by computed tomography-based dose calculations in patients with cervical carcinoma undergoing high-dose-rate brachytherapy (2007)
  • Author(s): Noda SE, Ohno T, Kato S, Ishii T, Saito O, Wakatsuki M, Tamaki T, Watanabe K, Nakano T, Tsujii H.
  • Journal Title: Int J Radiat Oncol Biol Phys. 69(1) Pages: 118-24
  • Peer Reviewed
• [Journal Article] Carbon ion radiotherapy for vaginal malignant melanoma : a case report (2007)
  • Author(s): Ohno T, Kato S, Sasaki E, Mizutani K, Tsujii H.
  • Journal Title: Int J Gynecol Cancer 17(5) Pages: 1163-6
  • Peer Reviewed
• [Journal Article] Clinical usefulness of CYFRA 21-1 for esophageal squamous cell carcinoma in radiation therapy (2007)
  • Author(s): Wakatsuki M, Suzuki Y, Nakamoto S, Ohno T, Ishikawa H, Kiyohara H, Kiyozuka M, Shirai K, Nakayama Y, Nakano T.
  • Journal Title: J Gastroenterol Hepatol 22(5) Pages: 715-9
  • Peer Reviewed
• [Book] 粒子線治療の歩みと現状p8-9、ここまできた重粒子線治療のすべてp18-21 (2010)
  • Author(s): 大野達也
  • Publisher: 上毛新聞社
• [Book] Gynecologic carcinoma. Delaney TF Koy HM (Eds.) Proton and Charged Particle Radiotherapy(1st edition. Philadelphia. Lippincott Williams & Wilkins) (2008)
  • Author(s): Nakano T, Suzuki Y, Kato S, Ohno T, Delaney TF.
• [Book] 放射線による皮膚障害 (2007)
  • Author(s): 大野達也, 辻井博彦
  • Total Pages: 368-371
  • Publisher: 中外医学社
• [Remarks] 群馬大学重粒子線医学研究センター
  • URL: http://heavy-ion.showa.gunma-u.ac.jp/index.html
• [Remarks] 放射線医学総合研究所重粒子医科学センター病院
  • URL: http://www.nirs.go.jp/hospital/index.shtml
• [Remarks] 放射線医学総合研究所ゲノム診断研究グループ
  • URL: http://133.63.22.22/radgenomics/index.php
• [Remarks] 放射線医学総合研究所分子病態イメージング研究グループ
  • URL: http://www.nirs.go.jp/research/division/mic/group/g_bunshi-byotai.html
• [Patent(Industrial Property Rights)] 放射線治療情報管理システム (2010)
  • Inventor(s): 鳥飼幸太, 加藤弘之, 大野達也, 山田聰, 山口進一, 福島伸哉, 中村昌彦, 三浦幸雄, 武井由佳, 簑原伸一, 福田茂一
  • Industrial Property Rights Holder: 群馬大学、東芝、放射線医学総合研究所
  • Industrial Property Number: PCT出願特願2010-02727
  • Filing Date: 2010-02-10
• [Patent(Industrial Property Rights)] 子宮頚部腺癌の診断又は子宮頸癌の予後の診断のためのマーカー (2008)
  • Inventor(s): 今井高志, 岩川眞由美, 加藤真吾, 大野達也
  • Industrial Property Rights Holder: 独立行政法人放射線医学総合研究所
  • Industrial Property Number: PCT出願PCT/JP2008/068920
  • Filing Date: 2008-10-10