2009 Fiscal Year Final Research Report

Structural analysis of collagen fiber of arterial wall in patients with abdominal aortic aneurysm

Research Project

Project/Area Number	19591475
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General surgery
Research Institution	The University of Tokyo
Principal Investigator	SHIGEMATSU Kunihiro The University of Tokyo, 医学部附属病院, 特任講師 (20215966)
Co-Investigator(Kenkyū-buntansha)	MIYATA Tetsuro 東京大学, 医学部附属病院, 准教授 (70190791) KOYAMA Hiroyuki 東京大学, 医学部附属病院, 客員准教授 (10241994) OKAMOTO Hiroyuki 東京大学, 医学部附属病院, 助教 (60348266) KIMURA Hideo 東京大学, 医学部附属病院, 助教 (60327070) FUKAYAMA Masahisa 東京大学, 医学部附属病院, 教授 (70281293)
Project Period (FY)	2006 – 2009
Keywords	血管外科学 / 腹部大動脈瘤 / 加齢変化 / コラーゲン線維
Research Abstract	The structure of adventitial collagen fiber of abdominal aorta is immature around the inferior mesenteric artery and the direction of the media l collagen fiber becomes more identical in proportion to the age. In patients with abdominal aortic aneurysm, additionally, the collagen density is remarkably decreasing. However, differently from the normal aorta, the direction of medial collagen was scattered and the type I collagen decreases in volume in AAA patients. These data suggest that AAA formation does not depend on the site specificity and aging but also other factors.