Molecular oncological study of thyroid cancer among atomic bomb survivors

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591525
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Radiation Effects Research Foundation
• Principal Investigator: HAMATANI Kiyohiro Radiation Effects Research Foundation, 放射線生物学/分子疫学部, 細胞生物学研究室長 (80344414)
• Co-Investigator(Kenkyū-buntansha): ITO Reiko 財団法人放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (30283790)
• Co-Investigator(Renkei-kenkyūsha): SODA Midori 財団法人放射線影響研究所, 長崎疫学部, 副部長 (00359457) ; EGUCHI Hidetaka 埼玉医科大学, 医学部, 准教授 (00260232)
• Project Period (FY): 2007 – 2009
• Keywords: 放射線関連成人甲状腺乳頭癌 / 染色体再配列 / RET / PTC再配列 / 再配列型ALK点突然変異 / BRAF点突然変異 / 原爆被爆者

Research Abstract

To clarify characteristics of gene alterations in adult-onset radiation-associated papillary thyroid cancer, molecular analyses were conducted focusing on gene alterations occurring at early stage of carcinogenesis. We found that cases having chimera gene (RET/PTC rearrangements) formed by fusion of 3' region of RET gene to 5' region of other genes significantly increased with increase of exposure dose, while cases with BRAF point mutation, which is frequently detected in sporadic (non-exposed) adult-onset papillary thyroid cancer, significantly decreased with exposure dose.

Research Products

• [Journal Article] Improved method for analysis of RNA present in long-term preserved thyroid cancer tissue of atomic-bomb survivors. (2010)
  • Author(s): Hamatani K, Eguchi H, Mukai M, Koyama K, Taga M, Ito R, Hayashi Y, Nakachi K
  • Journal Title: Thyroid 20 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Mechanisms of development of human adult-onset radiation-associated papillary thyroid cancer-Characteristics in early molecular events- (2009)
  • Author(s): Hamatani K, Takahashi K, Mukai M
  • Journal Title: Radiation Biology research Communications 44 Pages: 379-395
• [Journal Article] RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose. (2008)
  • Author(s): Hamatani K, Eguchi H, Ito R, Mukai M, Takahashi K, Taga M, Imai K, Cologne J, Soda M, Arihiro K, Fujihara M, Abe K, Hayashi T, Nakashima M, Sekine I, Yasui W, Hayashi Y, Nakachi K
  • Journal Title: Cancer Res 68 Pages: 7176-7182
  • Peer Reviewed
• [Journal Article] Sixty years of follow-up of Hiroshima and Nagasaki survivors: Current progress in molecular epidemiology studies. (2008)
  • Author(s): Nakachi K, Hayashi T, Hamatani K, Eguchi H, Kusunoki Y
  • Journal Title: Mut Res 659 Pages: 109-117
  • Peer Reviewed
• [Journal Article] Comparison of papillary thyroid carcinomas among atomic bomb survivor patients with and without BRAF gene mutation. (2007)
  • Author(s): Takahashi K, Eguchi H, Arihiro K, Ito R, Koyama K, Soda M, Cologne J, Hayashi Y, Nakata Y, Nakachi K, Hamatani K
  • Journal Title: Mol Carcinogenesis 46 Pages: 242-248
  • Peer Reviewed
• [Presentation] Chromosomal rearrangements and amplification of PIK3CA gene in papillary thyroid cancer among atomic-bomb survivors. (2009)
  • Author(s): Takahashi K, Taga M, Ito R, Nakachi K, Hamatani K
  • Organizer: 52nd Annual Meeting of Japan Radiation Research Society
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 20091111-20091113
• [Presentation] Molecular oncological analysis of adult-onset papillary thyroid cancer among atomic bomb survivors. (2009)
  • Author(s): Hamatani K, Takahashi K, Taga M, Ito R, Nakachi K
  • Organizer: 68th Annual Meeting of Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20091001-20091003
• [Presentation] Molecular oncology study on adult-onset papillary thyroid cancer among atomic-bomb survivors. (2009)
  • Author(s): Hamatani K, Takahashi K, Taga M, Ito R, Hayashi Y, Nakachi K
  • Organizer: 34th Annual Meeting of the European Thyroid Association
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 20090905-20090909
• [Presentation] Molecular characteristics in papillary thyroid cancer among atomic bomb survivors. (2008)
  • Author(s): Hamatani K, Takahashi K, Eguchi H, Taga M, Ito R, Imai K, Nakachi K
  • Organizer: The 67th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20081028-20081030
• [Presentation] Analysis of RAS point mutations in papillary thyroid cancer among atomic-bomb survivors. (2008)
  • Author(s): Takahashi K, Taga M, Ito R, Imai K, Nakachi K, Hamatani K
  • Organizer: 15th The Joint Meeting for Cancer prevention
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 20080522-20080523
• [Presentation] Gene alterations preferentially occurred in papillary thyroid cancer among atomic bomb survivors. (2008)
  • Author(s): Hamatani K, Eguchi H, Cologne J, Soda M, Abe K, Hayashi T, Nakashima M, Sekine I, Hayashi Y, Nakachi K
  • Organizer: 49th Late A-bomb Effects Research Meeting
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 2008-06-08
• [Presentation] Gene alterations preferentially occurred in papillary thyroid cancer among atomic-bomb survivors. (2007)
  • Author(s): Hamatani K, Eguchi H, Taga M, Ito R, Imai K, Takahashi K, Abe K, Fujihara M, Arihiro K, Nakachi K
  • Organizer: The 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20071003-20071005
• [Presentation] Gene alterations preferentially occurred in adult-onset papillary thyroid cancer among atomic-bomb survivors. (2007)
  • Author(s): Takahashi K, Eguchi H, Imai K, Hayashi Y, Nakachi K, Hamatani K
  • Organizer: 8th Korea-Japan Cancer and Aging Symposium
  • Place of Presentation: Gifu, Japan
  • Year and Date: 20070810-20070811
• [Presentation] Gene Alterations Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors. (2007)
  • Author(s): Hamatani K, Eguchi H, Taga M, Nakachi K
  • Organizer: 13th International Congress of Radiation Research
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20070708-20070712
• [Presentation] HIROSHIMA 60 YEARS: Monitoring of Survivors-Current Progress in Molecular Epidemiology Studies. (2007)
  • Author(s): Nakachi K, Hayashi T, Hamatani K, Eguchi H, Kusunoki Y
  • Organizer: 5th International Conference on Environmental Mutagens in Human Populations
  • Place of Presentation: Antalya, Turkey
  • Year and Date: 20070520-20070524