Analysis of liver regeneration and liver fibrosis focusing on mechanical stress

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hyogo College of Medicine
• Principal Investigator: IIMURO Yuji Hyogo College of Medicine, 医学部, 准教授 (30252018)
• Co-Investigator(Kenkyū-buntansha): FUJIMOTO Jirou 兵庫医科大学, 医学部, 教授 (90199373) ; HIRANO Tadamichi 兵庫医科大学, 医学部, 講師 (90340968) ; UYAMA Naoki 兵庫医科大学, 医学部, 助教 (70402873)
• Project Period (FY): 2007 – 2008
• Keywords: 再生医学 / 細胞・組織 / 流体工学 / シミュレーション

Research Abstract

ヒトにおける切除後肝再生のメカニズムをメカニカルストレス応答の面から解析し、相対的門脈血流量の増加(相対的ストレス増加)が、領域別肝再生を制御している可能性が明らかとなった。また、肝臓におけるメカニカルストレス受容体の存在が具体的に示唆された。

Research Products

• [Presentation] Computational simulation of peri-operative change in portal blood flow dynamics in fibrotic and non-fibrotic human livers. (2009)
  • Author(s): Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Akito Yada, Jiro Fujimoto.
  • Organizer: 19^<th> Conference of the Asian Pacific Association for the Study of the Liver
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090213-15
• [Presentation] NON-UNIFORM REGIONAL LIVER REGENERATION AFTER HEPATIC SURGERY WELL CORRELATES WITH COMPUTATIONALLY SIMULATED INCREASES IN BLOOD FLOW AND PRESSURE IN PORTAL BRANCHES. (2008)
  • Author(s): Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.
  • Organizer: 43rd Annual Meeting of the European Association for the Study of the Liver
  • Place of Presentation: Milan, Italy
  • Year and Date: 20080423-27
• [Presentation] Non-uniform increases in blood flow and pressure in portal branches after liver surgery assessed by computational flow dynamics simulation well correlate with the regional liver regeneration. (2008)
  • Author(s): Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.
  • Organizer: 18^<th> Conference of the Asian Pacific Association for the Study of the Liver
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20080323-26
• [Presentation] Computational flow dynamics simulation of portal branches is useful for analyzing the mechanism of non-uniform regional liver regeneration after surgical resection. (2007)
  • Author(s): Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.
  • Organizer: 58^<th> Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, U.S.A.
  • Year and Date: 20071102-06