2009 Fiscal Year Final Research Report

Molecular biological analysis about mechanism of autoregulation in cerebral blood flow

Research Project

Project/Area Number	19591657
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	Hirosaki University
Principal Investigator	OHKUMA Hiroki Hirosaki University, 大学院・医学研究科, 教授 (40211099)
Co-Investigator(Kenkyū-buntansha)	NAKANO Takahiro 弘前大学, 大学院・医学研究科, 講師 (20400137) SHIMAMURA Norihito 弘前大学, 大学院・医学研究科, 講師 (40312491)
Project Period (FY)	2007 – 2009
Keywords	脳血管障害学
Research Abstract	In order to investigate the possibility that the intraparenchymal arterioles show remodeling based on phenotypic modulation of smooth muscle cells which results in the disorder of cedrebral blood flow autoregulation after subarachnoid hemorrhage, the experimental study using rabbits were performed. After the subarachnoid hemorrhage, cedrebral blood flow autoregulation was disturbed in association with the degree of the remodeling in the arterioles. The remodeling and the disorder of autoregulation could not be improved by intrathecal administration of antisense oligo DNA for several factors related to the pathology of remodeling. On the other hand, administration of several drugs affecting intracellular signaling transduction could improve the remodeling and the disorder of autoregulation.

(3 results)