2009 Fiscal Year Final Research Report
Study of therapeutic effects of vessel-permeable 11R protein on stroke
| Project/Area Number |
19591677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
ONO Shigeki Okayama University, 大学院・医歯薬学総合研究科, 助教 (40335625)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Koji 岡山大学, 岡山大学病院, 講師 (40294467)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70236785)
SUGIU Kenji 岡山大学, 岡山大学病院, 講師 (40325105)
ICHIKAWA Tomotsugu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10362964)
MATSUI Hideki 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157234)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脳血管障害学 / 蛋白質セラピー / 11R |
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| Research Abstract |
We made fusion proteins of 11R with superoxide-dismutase, TGF-beta、low-density lipoprotein receptor, endothelial NOS, and superoxide-dismutase by using genetic recombination technique. endothelial NOS-11R transmitted into the brain blood vessels, and it made these vessels dilated, successfully. (Stroke. 38 : 1354-61, 2007). We also revealed that 11R protein could transmit into any layers of arterial vessels, and even large molecular weight proteins could penetrate into the any layers of the vessels with 11R protein. Meanwhile, we observed no signals of 11R in the brain parenchyma.
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[Presentation] Conus medullaris arteriovenous malformation (AVM)の1例─直達手術と血管内手術のcombined approachの有用性─2009
Author(s)
大熊佑, 杉生憲志, 徳永浩司, 三好康之, 西田あゆみ, 伊丹尚多, 菱川朋人, 近藤聡彦, 有光帥二, 安原隆雄, 小野成紀, 伊達勲
Organizer
第18回中国四国脳神経血管内手術研究会
Place of Presentation
高知
Year and Date
20090900
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[Presentation] 大浅錐体神経鞘腫の1例2009
Author(s)
菱川朋人, 安原隆雄, 上利崇, 島津洋介, 小野成紀, 伊達勲
Organizer
第67回(社)日本脳神経外科学会中国四国支部学術集会
Place of Presentation
高松
Year and Date
20090400
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