2009 Fiscal Year Final Research Report
Neurotrophic and neuralizing activities of bone marrow stromal cells
| Project/Area Number |
19591697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
NAKAO Naoyuki Wakayama Medical University, 医学部, 講師 (30301435)
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| Co-Investigator(Kenkyū-buntansha) |
ITAKURA Toru 和歌山県立医科大学, 医学部, 教授 (40100995)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 再生医療 |
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| Research Abstract |
The present study was designed to test the neurotrophic and neuralizing activities of bone marrow stromal cells (BMSC) derived from adult mice. Treatment with conditioned media derived from BMSC cultures significantly prevented the death of dopamine (DA) neurons in in vitro. BMSC also facilitated an efficient induction of DA neurons from ES cells. The present study indicates that BMSC may have the neurotrophic and neuralizing activities, and raises the possibility that they can be applied in regenerative cell therapy in Parkinson's disease.
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