2010 Fiscal Year Final Research Report
The mechanism of neuroprotective effect of anesthetics related to MAP kinases and calcium
| Project/Area Number |
19591790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
SHIBUTA Satoshi Osaka University, 医学系研究科, 助教 (20324767)
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| Co-Investigator(Kenkyū-buntansha) |
MASHIMO Takashi 大阪大学, 大学院・医学研究科, 教授 (10110785)
KAMIBAYASHI Takahiko 大阪大学, 大学院・医学研究科, 助教 (10273640)
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| Project Period (FY) |
2007 – 2010
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| Keywords | MAPキナーゼ / カルシウム / 麻酔薬 / 一酸化窒素 / 神経保護作用 / 温度 |
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| Research Abstract |
Edaravone, a free radical scavenger, has been shown to be neuroprotective in in vivo and in vitro conditions. However, the impact of small temperature variations on the molecule remains unknown. Our study found that the temperature of the CNS is a potential factor in determining whether edaravone confers a potent neuroprotective effect when applied during prolonged hypoxic insults.
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