2010 Fiscal Year Final Research Report
Development of pharmacological postconditioning against liver ischemia reperfusion injury, and clarification of mechanisms
| Project/Area Number |
19591805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
CHO Sungsam Nagasaki University, 病院, 講師 (90325655)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 肝臓 / 虚血再灌流 / ポストコンディショニング / ホスホジエステラーゼ阻害薬 / Rhoキナーゼ阻害薬 |
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| Research Abstract |
We showed that both phosphodiesterase III inhibitors and Rho kinase inhibitors administered just before reperfusion protect against liver ischemia reperfusion injury and apoptosis. This protective effect was attenuated by wortmannin, a PI3K-Akt inhibitor, PD-98059, an ERK inhibitor, or L-NAME, a eNOS inhibitor. Both phosphodiesterase III inhibitors and Rho kinase inhibitors administered just before reperfusion activated PI3K-Akt, ERK, or eNOS. Thus both phosphodiesterase III inhibitors and Rho kinase inhibitors could have postconditioning effects via PI3K-Akt, ERK, or eNOS activation.
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Research Products
(11 results)
