2009 Fiscal Year Final Research Report
Proteomics approach to discover biomarker for kidney transplant rejection
| Project/Area Number |
19591885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
YOSHIDA Kazunari Kitasato University, 医学部, 准教授 (10174921)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Yasuo 北里大学, 医学部, 講師 (60286359)
OISHI Masamichi 北里大学, 理学部, 講師 (40233027)
KODERA Yoshio 北里大学, 理学部, 准教授 (60265733)
BABA Shiro 北里大学, 医学部, 教授 (00051889)
OKUSA Hiroshi 北里大学, 医学部, 助教 (70337963)
MAEDA Tadakazu 北里大学, 理学部, 教授 (90265728)
MURAMOTO Masatoshi 北里大学, 医学部, 助教 (50265633)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 腎移植 / 血中抗体 / プロテオーム解析 |
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| Research Abstract |
The rejection is the most serious problem in renal transplantation, but there is no clear clinical marker to diagnose at an early stage. In this study, we developed the effective pretreatment method of urine followed by proteor is analysis using agarose two-dimensional electrophoresis. With this method, we detected eight rejection-associated proteins and identified them by LC-MS/MS analysis.
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[Journal Article] Seraching for new biomarkers of bladder cancer based on proteomic analysis.2008
Author(s)
Okusa H., Kodera Y, Oh-ishi M., Minamida M., Tsuchida M., Kavoussi N., Matsumoto K., Sato T, Iwamura M., Maeda T., Baba S.
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Journal Title
J. Elecrophoresis 52
Pages: 19-24
Peer Reviewed
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[Presentation] 独自のペプチド分析法による大腸癌マーカーペプチドの探索と評価2008
Author(s)
小寺義男, 川島祐介, 福冨俊之, 高橋広樹, 相野谷学, 丸橋正弘, 松井崇, 平賀啓介, 曽川一幸, 朝長毅, 野村文夫, 前田忠
Organizer
日本ヒトプロテオーム機構(JHUPO)第6回大会
Place of Presentation
大阪府茨木市
Year and Date
2008-07-30
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