2009 Fiscal Year Final Research Report
Evaluation of effectiveness for endometriosis treatment using cine-mode MRI
| Project/Area Number |
19591908
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
KONNO Ryo Jichi Medical University, 医学部, 教授 (70271905)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 子宮内膜症 / 月経痛 / MRI / 子宮収縮 / サイトカイン / ロイコトリエン |
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| Research Abstract |
The cine-mode MRI suggested that the area of the low signal in the muscle layer right under the endometrium was broad and sustained in the patients with severe dysmenorrhea. Ischemia and pain was caused in the uterine muscle with strong shrinkage. Moreover, the value of serum osteopontin was useful biomarker to judge the severity of symptoms and to detect ovarian cancer related with endometriosis. The prospective, double-blind, randomized, placebo-controlled study resulted that leukotorien recepter antagonist was an effective alternative for treatment of endometriosis. It resulted that further studies using the cine-mode MRI and the value of serum osteopontin are enable to evaluate the severity of dysmenorrhea and the effectiveness of the treatment for endometriosis.
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[Journal Article] Efficacy of montelukast, a leukotriene receptor antagonist, for the treatment of dysmenorrhea: A prospective, double-blind, randomized, placebo-controlled study2009
Author(s)
Fujiwara H, Konno R, Netsu S, Odagiri K, Taneichi A, Takamizawa S, Ohwada M, Suzuki M.
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Journal Title
Eur J Obstet Gynecol Reprod Biol. (Epub ahead of print)
Peer Reviewed
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[Journal Article] Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis2008
Author(s)
Netsu, S., Konno, R., Odagiri, K., Soma, M., Fujiwara, H, Suzuki, M.
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Journal Title
Fertil Steril 90(4Suppl)
Pages: 1496-502
Peer Reviewed
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