2009 Fiscal Year Final Research Report
Model experiments on BPPV mechanism and estrogen receptor distribution within the vestibular organ.
| Project/Area Number |
19591989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
SUZUKI Mamoru Tokyo Medical University, 医学部, 教授 (80116607)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 良性発作性頭位めまい症 / 耳石 / 前庭 / 更年期 / 卵形嚢 / 半規管 / エストロゲン |
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| Research Abstract |
Estrogen receptors (ER) in the vestibular organ were investigated by immunochemical method. ER was distributed more in the female and it markedly decreased in the elderly animals. Dislodge of the otoconia due to mechanical stimulus was more pronounced in the elderly and menopausal animals, suggesting otoconial metabolic disorder contributes to emergence of benign paroxysmal positional vertigo. Stability of the otoconia placed on the utricular macula was studied using the frog model. The otoconial stability depends on condition of the utricular macula, but it became stabilized in 5 min., suggesting that the physical therapy is still useful even if the utricular macula is disturbed.
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Research Products
(9 results)
