2009 Fiscal Year Final Research Report
Pathogenesis and developing mechanism of pars flaccida cholesteatoma, and its prevention and surgical treatment
| Project/Area Number |
19591991
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MORIYAMA Hiroshi Jikei University School of Medicine, 医学部, 教授 (60125036)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Hiromi 東京慈恵会医科大学, 医学部, 准教授 (60234762)
SHIWA Masanori 東京慈恵会医科大学, 医学部, 講師 (20235766)
TANAKA Hiroyasu 東京慈恵会医科大学, 医学部, 講師 (40266648)
YOSHIKAWA Mamoru 東京慈恵会医科大学, 医学部, 講師 (50277092)
UCHIMIZU Hiroki 東京慈恵会医科大学, 医学部, 講師 (00307414)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 弛緩部型真珠腫 / 中耳粘膜再生 / 遺伝子解析 / 中耳粘膜ガス換気能 / 上皮増殖 / 上皮分化 / 線維芽細胞 / 手術術式 |
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| Research Abstract |
The selection of the proper operation (tympanoplasty) according to the condition of cholesteatoma is important to prevent recurrent cholesteatomas and it contoribute to the hearing improvement. The formation of cholesteatoma and extention of the epithelium are considered to be extended by vicious circle, such as the hyperprpliferation and differentiation of epithelium by autocrine or paracrine system between keratinocytes and fibroblasts, the disturbance of epithelial migration, and continuing of inflammation.
Concerning the regeneration of the middle ear mucosal epithelium, we succeeded in preparing the cultured middle ear mucosal tissue and transplantation this tissue to the middle ear cavity in animal study. In other words, we transplanted the rabbit's three-dimensional cultured middle ear mucosa to the opposite side of the middle ear cavity. The regenerated mucosa was similar to the normal middle ear mucosa morphologically and physically animal study.
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