2009 Fiscal Year Final Research Report
Analysis of the retinal fascin gene for retinitis pigmentosa in zebrafish
| Project/Area Number |
19592018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
SAISHIN Yoshitsugu Osaka University, 医学部, 准教授 (30379193)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIKAWA Motokazu 大阪大学, 医学系研究科, 助教 (70419472)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 眼科学 / 遺伝子 / 網膜色素変性 |
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| Research Abstract |
Retinal fascin gene has been analyzed to determine its role in Japanese patients with autosomal dominant retinitis pigmentosa. We found the retinal fascin gene in zebrafish as well as in human. Morphological changes have not been found, however, some functional change might occur in transgenic fish, which could be helpful to determine the cause of retinitis pigmentosa.
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