2010 Fiscal Year Final Research Report
The research for repair of chronic spinal cord injury using autologas cells, growth factor and artificial extracellular matrix.
| Project/Area Number |
19592074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
KATAOKA Kazuya Kyoto University, 医学研究科, 非常勤講師 (10314189)
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| Co-Investigator(Kenkyū-buntansha) |
NOSE Kensuke 京都大学, 医学研究科, 非常勤講師 (80379057)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 慢性期脊髄損傷 / 細胞外マトリクス / アルギン酸ゲル / bFGF / 徐放 / ヘパリン様ペプチド |
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| Research Abstract |
We made the device for making injury to spinal cords of rats. Using this device we could make fixed damage to spinal cords. After 2 weeks, we observe fixed size cavities in the spinal cords using immunohistochemical staining. We injected the alginate gel and the bFGF applied alginate gel. After injection, we investigate the spinal cord. We confirmed inhibition of enlargement of the cavities and partial regeneration of nerve fibers, but we could not find statistically significance.
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