2009 Fiscal Year Final Research Report
The role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury.
| Project/Area Number |
19592101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
MASUNO Tomohiko Nippon Medical School, 医学部, 助教 (00318528)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Norio 日本医科大学, 医学部, 助教 (30409205)
YOKOTA Hiroyuki 日本医科大学, 医学研究科, 教授 (60182698)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ショック / 腸管リンパ液 / 脂質メディエータ / 腸管虚血 / ホスホリパーゼA2 / 臓器障害 |
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| Research Abstract |
The purpose of this study is to determine the role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. Mesenteric ischemia increases or generates PLA2 protein in PSML. PLA_2 inhibition, in vitro and in vivo, attenuates the neutrophil priming effect of PSML and prevents acute lung injury in a two-event model.
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