2009 Fiscal Year Final Research Report
The elucidation and the strategy for multiple organ dysfunction syndrome following severe burn injury.
| Project/Area Number |
19592102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SATO Norio Nippon Medical School, 医学部, 助教 (30409205)
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| Co-Investigator(Kenkyū-buntansha) |
MASUNO Tomohiko 日本医科大学, 医学部, 助教 (00318528)
YOKOTA Hiroyuki 日本医科大学, 大学院・医学研究科, 教授 (60182698)
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| Research Collaborator |
HIRAKAWA Keiko 日本医科大学, 医学部, 助教 (30165162)
KOIKE Kaoru 京都大学, 大学院・医学研究科, 教授 (10267164)
KOBAYASHI Tetsuyuki お茶の水女子大学, 大学院・人間文化創成科学研究科, 教授 (50178323)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 免疫調整栄養剤 / 脂肪酸代謝 / 腸管粘膜障害 / 腸上皮細胞 / n-3系脂肪酸 |
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| Research Abstract |
One of the major complications following severe burn is an infection.
This causes increasing high mortality rate and prolonged hospital stay. Early enteral nutrition is an important to preserve immune function and decrease complications. This study focused metabolism of fatty acids under inflammation using imunomodulating diets which usually is used clinically. First we investigated the basal experiment related with a continuous enteral nutrition of rat. Second we tested to change of metabolites following LPS stimulation as second hit after burned rat using 1H-NMR. We observed the different peak of metabolites between the groups.
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Research Products
(2 results)
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[Presentation] 1H-NMR based metabolomics study of the intestinal epithelial cell (IEC-6) under the oxidative stress.2010
Author(s)
K Nakata, N Sato, T. Asakura, K. Hirakawa, R Zhu, T Masuno, S Shiraishi, Y Ohno, K Koike, H Yokota.
Organizer
5^<th> ASC (Academic Surgical Congress)
Place of Presentation
San Antonio, Texas USA
Year and Date
20100200
