2009 Fiscal Year Final Research Report
Roll of interleukin-32 in inflammatory bone resorption caused by periodontopathic bacterium
| Project/Area Number |
19592123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
TSUJISAWA Toshiyuki Kyushu Dental College, 歯学部, 助教 (60265006)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIHARA Tatsuji 九州歯科大学, 歯学部, 教授 (80192251)
INOUE Hiromasa 九州歯科大学, 歯学部, 准教授 (20137326)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 炎症 / サイトカイン / インターロイキン / インターロイキン / リポ多糖 / 自然免疫 / 歯周病原性細菌 |
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| Research Abstract |
We examined whether lipopolysaccaride (LPS) derived from Aggregatibacter actinomycetemcomitans, one of periodontopathic bacteria, induce expression of interlukin-32. We also analyzed the induction mechanism of IL-32 in human monocyte. Scince an inhibitor of NF-kB, one of downstream signaling of Toll-like receptor 4, inhibits the expression of IL-32, it was suggested that NF-kB activation was involved in the induction of IL-32 by LPS.
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