2009 Fiscal Year Final Research Report
Studies on the mechanisms of regulation of catecholamine release in the nucleus accumbens
| Project/Area Number |
19592160
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
SAIGUSA Tasashi Nihon University, 歯学部, 専任講師 (50277456)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Satoshi 日本大学, 歯学部, 助教 (00386096)
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| Project Period (FY) |
2007 – 2009
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| Keywords | カテコラミン / 大脳基底核 / 口腔ジスキネジア / 麻薬性鎮痛薬 / 鎮痛補助薬 |
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| Research Abstract |
Oral dyskinesia is a neurological syndrome associated with aging or use of drugs for Parkinson's disease and antipsychotics. It is characterized by repetitive stereotyped oral movement The detaned biological basis of the disorder remains unclear, but the phamaco-behavioural studies suggest that enhance of dopamine function in the nucleus accumbens and striatum plays a pivotal role for the induction of repetitive jaw movements of rats. Therefore, in the present study, we nvestigated the mechanisms of increase in accumbal and striatal dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.
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[Journal Article] Role of GABAB receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats.2008
Author(s)
Saigusa T, Aono Y, Mizoguchi N, Iwakami T, Takada K, Oi Y, Ueda K, Koshikawa N, Cools A R
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Journal Title
Eur J Pharmacol 581
Pages: 276-282
Peer Reviewed
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[Journal Article] Role of GABAA receptors in the endomorphM-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats.2008
Author(s)
Aono Y, Saigusa T, Mizoguchi N, Iwakami T, Takada K, Gionhaku N, Oi Y, Ueda K, Koshikawa N, Cools A R
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Journal Title
Eur J Pharmacol 580
Pages: 87-94
Peer Reviewed
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[Remarks] Saieusa T, Monitoring of extracellular catecholamine levels in the dorsal striatum and the nucleus accumbens by in vivo microdialysis in freely moving rats in 25th RRC (BSI Research Resource Center) Educational Seminar "HPLC-Electrochemical Detection & Microdialysis (Basic and Applied technologies)," Seminar, 2009年12月11日, RIKEN Brain Science Institute,埼玉県和光市
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