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2009 Fiscal Year Final Research Report

Study on endocrine disruptors of dental materials using an amphibian system

Research Project

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Project/Area Number 19592239
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionHiroshima University

Principal Investigator

NOMURA Yuji  Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (80218370)

Co-Investigator(Kenkyū-buntansha) SAWAJIRI Masahiko  広島大学, 大学院・医歯薬学総合研究科, 助教 (20325195)
OKAZAKI Masayuki  広島大学, 大学院・医歯薬学総合研究科, 教授 (30107073)
TAKAHASHI Tohru  熊本保健科学大学, 保健科学部, 教授 (70369122)
Project Period (FY) 2007 – 2009
Keywords生体材料 / 環境ホルモン / 両生類 / 歯学 / 安全性評価
Research Abstract

Risk assessment of EDCs have gradually been clarified by the screening test that used a yeast and bacteria such as competitive estrogen receptor-binding assay and reporter assay of genes containing estrogen-responsive promoters about these chemical substance. However, bioassay systems are also needed to elucidate direct effects of the compounds on animals and humans because environmental compounds may be metabolically transformed into estrogenic or non-estrogenic substances in the body or cells. Therefore, the screening test of estrogen and thyroid hormone activities is needed and we developed the new system using an amphibian system. By this system we evaluated the estrogen and thyroid hormone activities of dental materials. As the result, some of dental materials indicated the estrogen and thyroid hormone activities.

  • Research Products

    (12 results)

All 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (2 results)

  • [Journal Article] Hydroxylated polychlorinated biphenyls (OH-PCBs) induce vitellogenin through estrogenic activity in primary-cultured hepatocytes of the Xenopus laevis2010

    • Author(s)
      K. Nomiyama, Y. Nomura, T. Takahashi, Y. Uchiyama, K. Arizono, R. Shinohara
    • Journal Title

      Chemosphere 78

      Pages: 800-806

    • Peer Reviewed
  • [Journal Article] Effects of high-dose major components in oral disinfectants on the cell cycle and apoptosis in primary human gingival fibroblasts in vitro2010

    • Author(s)
      Y. Nomura, U.K. Bhawal, R. Nishikiori, M. Sawajiri, T. Maeda, M. Okazaki
    • Journal Title

      Dental Materials Journal 29

      Pages: 175-183

    • Peer Reviewed
  • [Journal Article] Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts2008

    • Author(s)
      R. Nishikiori, Y. Nomura, M. Sawajiri, K. Masuki, I. Hirata, M. Okazaki
    • Journal Title

      J Dent 36

      Pages: 993-998

    • Peer Reviewed
  • [Journal Article] Loss of 14-3-3 Sigma Protein Expression and Presence of Human Papillomavirus Type 16 E6 in Oral Squamous Cell Carcinoma2008

    • Author(s)
      UK. Bhawal, M. Sugiyama, Y. Nomura, H. Kuniyasu, K. Tsukinoki
    • Journal Title

      Arch Otolaryngol Head Neck Surg 134

      Pages: 1055-1059

    • Peer Reviewed
  • [Journal Article] Okazaki, Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds.2007

    • Author(s)
      I. Hirata, Y. Nomura, M. Ito, A. Shimazu, M. Okazaki
    • Journal Title

      J Artif Organs 10

      Pages: 212-217

    • Peer Reviewed
  • [Journal Article] Okazaki, Apoptotic and necrotic influence of dental resin polymerisation initiators in human gingival fibroblast cultures2007

    • Author(s)
      K. Masuki, Y. Nomura, U.K. Bhawal, M. Sawajiri, I. Hirata, Y. Nahara, M. Okazaki
    • Journal Title

      Dental Materials Journal 26

      Pages: 861-869

    • Peer Reviewed
  • [Journal Article] Immobilization of Simulated Reducing Agent at the Surface of SiO2 fillers in Dental Composite Resins2007

    • Author(s)
      S. Shibata, I. Hirata, Y. Nomura, K. Shirai, M. Fujitani, H. Shintani, M. Okazaki
    • Journal Title

      Dental Materials Journal 26

      Pages: 568-574

    • Peer Reviewed
  • [Journal Article] Expression of MMP-13 in osteoblast cells and rat tibia after exposure to gamma rays or accelerated carbon ions2007

    • Author(s)
      M. Sawajiri, S. Takinami, T. Uchida, Y. Nomura, J. Mizoe, S. Banik, K. Tanimoto
    • Journal Title

      Physica Medica 23

      Pages: 73-79

    • Peer Reviewed
  • [Journal Article] High-risk human papillomavirus type 16 E7 oncogene associates with Cdc25A over-expression in oral squamous cell carcinoma2007

    • Author(s)
      U.K. Bhawal, M. Sugiyama, Y. Nomura, M. Sawajiri, K. Tsukinori, M. Ikeda, H. Kuniyama
    • Journal Title

      Virchows Arch 450

      Pages: 65-71

    • Peer Reviewed
  • [Journal Article] UCN-01 (7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primary and metastatic oral cancer cell lines in vitro, Oral Surgery, Oral Medicine, Oral pathology2007

    • Author(s)
      A. Otsubo, U.K. Bhawal, Y. Nomura, Y. Mitani, K. Ozawa, H. Kuniyasu, M. Sugiyama
    • Journal Title

      Oral Radiology and Endoontics 103

      Pages: 391-397

    • Peer Reviewed
  • [Presentation] 紫外線吸収剤の内分泌攪乱作用に関する研究2009

    • Author(s)
      林田知美, 野村雄二, 錦織良, 平田伊佐雄, 岡崎正之
    • Organizer
      第53回日本歯科理工学会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-12
  • [Presentation] 感染薬の細胞障害性とアポトーシスに関する研究2008

    • Author(s)
      錦織良, 野村雄二, 増木恒平, 園田喜子, 平田伊佐雄, 岡崎正之
    • Organizer
      第52回日本歯科理工学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21

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Published: 2011-06-18   Modified: 2016-04-21  

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