2009 Fiscal Year Final Research Report
Fibulin upregulated by mechanical strain controls the formation of oxytalan fibers.
| Project/Area Number |
19592391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
TSURUGA Eichi Fukuoka Dental College, 歯学部, 准教授 (30295901)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 歯根膜 / オキシタラン線維 / 弾性系線維 / 細胞外基質 / 線維芽細胞 |
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| Research Abstract |
Human periodontal ligaments (PDL) contain oxytalan fibers. However, the behavior of oxytalan fibers is unclear. We hypothesized that the fibulin-5 contributes to oxytalan fiber formation under mechanical strain. Fibrillin-1 contains the RGD motif. We subjected PDL fibroblasts to stretching strain. The oxytalan fibers coalesced by stretching. Fibulin-5 colocalizes on oxytalan fibers. Stretching increased fibulin-5 gene expression. The fibulin-5 suppression inhibited the coalescence of oxytalan fibers. The treatment with the integrin αvβ3 antagonist inhibited fibrillin-1 deposition. These results suggest that fibulin-5 may control the formation of oxytalan fibers bundles in PDL.
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