2009 Fiscal Year Final Research Report
Role of T cells in the onset of postherpetic neuralgia.
| Project/Area Number |
19603013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
TAKEDA Masako International University of Health and Welfare, 大学病院, 講師 (50433628)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKASAKI Ichiro (00397176)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 帯状疱疹後神経痛 / HLA遺伝子 / 帯状疱疹痛モデルマウス / T細胞 |
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| Research Abstract |
Dorsal Root Ganglion (DRG) in the postherpetic neuralgia model mouse have shown the possibility that CD4 positive T cells are involved in the onset of postherpetic neuralgia. If CD4 positive T cells are involved in the onset of postherpetic neuralgia, CD4 knockout mouse will not develop to postherpetic neuralgia from herpes zoster. But in this study, there were no significant differences between control mouse and CD4 knockout mouse as to the onset of postherpetic neuralgia. Therefore it is suggested that MHC genes (H-2^b) itself are directly involved in the onset of postherpetic neuralgia.
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Research Products
(2 results)
