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2009 Fiscal Year Final Research Report

Functional role of inhibitory neurons in the signal processing of the trigeminal pain

Research Project

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Project/Area Number 19603015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionUekusa Gakuen University (2008-2009)
Teikyo University (2007)

Principal Investigator

KUWANA Shun-ichi  Uekusa Gakuen University, 保健医療学部, 教授 (70129998)

Co-Investigator(Kenkyū-buntansha) HOSOKAWA Yuki  慶應義塾大学, 医学部, 助手 (00348765)
Project Period (FY) 2007 – 2009
Keywords三叉神経痛 / 三叉神経脊髄路核尾側亜核 / 遺伝子操作マウス / ガンマアミノ酪酸
Research Abstract

We found that inhibitory GABAergic neurons in the trigeminal subnucleus caudalis (Sp5C) of GAD67-GFP knock-in mouse received exclusively excitatory postsynaptic inputs, and were characterized by multipolar-shaped somata. Furthermore, we showed that an analgesic action of carbamazepine resulted from the large depression of non-GABAergic neuron in the Sp5C compared with that of GABAergic neuron.

  • Research Products

    (18 results)

All 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (7 results) Book (1 results)

  • [Journal Article] Effect of JM-1232(-), a new sedative on central respiratory activity in newborn rats.2010

    • Author(s)
      Kuribayashi J, Kuwana S, Hosokawa Y, Hatori E, Takeda J.
    • Journal Title

      Adv Exp Med Biol 669

      Pages: 115-118

    • Peer Reviewed
  • [Journal Article] Laudanosine has no effects on respiratory activity but induces non-respiratory excitement activity in isolated brainstem-spinal cord preparation of neonatal rats.2010

    • Author(s)
      Sakuraba S, Hosokawa Y, Kaku Y, Takeda J, Kuwana S
    • Journal Title

      Adv Exp Med Biol 669

      Pages: 177-180

    • Peer Reviewed
  • [Journal Article] 中枢性呼吸調節機構に対するニコチンおよびニコチン性アセチルコリン受容体拮抗剤の影響-新生ラットの単離脳幹脊髄標本を用いた研究-2009

    • Author(s)
      桑名俊一, 齋藤基一郎, 小池和子
    • Journal Title

      植草学園大学紀要 1

      Pages: 29-35

    • Peer Reviewed
  • [Journal Article] Donepezil partially reverses buprenorphine-induced central respiratory depression in anesthetized rabbits.2009

    • Author(s)
      Sakuraba S, Kuribayashi J, Tsujita M, Arisaka H, Takeda J, Yoshida K, Kuwana S
    • Journal Title

      Biological Research 42

      Pages: 469-475

    • Peer Reviewed
  • [Journal Article] The central respiratory chemoreceptor: Where is it located?2009

    • Author(s)
      Okada Y, Kuwana S, Chen Z, Ishiguro M, Oku, Y.
    • Journal Title

      Adv Exp Med Biol. 648

      Pages: 377-385

    • Peer Reviewed
  • [Journal Article] CO2-sensitivity of GABAergic neurons in the ventral medullary surface of GAD67-GFP knock-in neonatal mice.2008

    • Author(s)
      Kuribayashi J, Sakuraba S, Hosokawa Y, Hatori, E, Tsujita, M, Takeda, J, Yanagawa, Y, Obata K, Kuwana S
    • Journal Title

      Adv Exp Med Biol 605

      Pages: 338-42

    • Peer Reviewed
  • [Journal Article] Chemosensitive neuronal network organization in the ventral medulla analyzed by dynamic voltage-imaging.2008

    • Author(s)
      Okada Y, Kuwana S, Masumiya H, Kimura N, Chen Z, Oku Y
    • Journal Title

      Adv Exp Med Biol 605

      Pages: 353-358

    • Peer Reviewed
  • [Journal Article] Neural mechanisms of sevoflurane-induced respiratory depression in newborn rats.2008

    • Author(s)
      Kuribayashi J, Sakuraba S, Kashiwagi M, Hatori E, Tsujita M, Hosokawa Y, Takeda J, Kuwana S
    • Journal Title

      Anesthesiology 109,2

      Pages: 233-42

    • Peer Reviewed
  • [Journal Article] Dendritic backpropagation and synaptic plasticity in the mormyrid electrosensory lobe.2008

    • Author(s)
      Engelmann J, van den Burg E, Bacelo J, de Ruijters M, Kuwana S, Sugawara Y, Grant K
    • Journal Title

      J Physiol Paris 102(4-6)

      Pages: 233-45

    • Peer Reviewed
  • [Journal Article] (2007) Antagonism of morphine-induced central respiratory depression by donepezil in the anesthetized rabbit.2007

    • Author(s)
      Tsujita M, Sakuraba S, Kuribayashi J, Hosokawa Y, Hatori E, Okada Y, Kashiwagi M, Takeda J, Kuwana S.
    • Journal Title

      Biological Research 40,3

      Pages: 339-46

    • Peer Reviewed
  • [Presentation] Laudanosine has no effects on respiratory activity but inducees non-respiratory excitement activity in isolated brainstem-spinal cord preparation of neonatal rats.2009

    • Author(s)
      Sakuraba S, Hosokawa Y, Takeda J, Kuwana S.
    • Organizer
      XIth Oxford Conference on Modeling and Control of Breathing
    • Place of Presentation
      Nara, Japan
    • Year and Date
      20090000
  • [Presentation] Effect of a new sedative, JM-1232(-) on central respiratory activity in newborn rats.2009

    • Author(s)
      Kuribayashi J, Kuwana S, Sakuraba S, Hosokawa Y, Takeda J.
    • Organizer
      XIth Oxford Conference on Modeling and Control of Breathing
    • Place of Presentation
      Nara, Japan
    • Year and Date
      20090000
  • [Presentation] Effect of carbamazepine on activities of GABAergic and non-GABAergic neurons in themouse trigeminal nucleus caudalis.2009

    • Author(s)
      Kuwana S, Hosokawa Y, Kuribayashi J, Sakuraba S, Yanagawa Y, Obata K.
    • Organizer
      The 36th Congress of the International Union of Physiological Science
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20090000
  • [Presentation] 三叉神経脊髄路核におけるGABA性ニューロンの特性:GAD67-GFPノックインマウスを用いた研究2008

    • Author(s)
      細川幸希, 栗林淳也, 辻田美紀, 武田純三, 柳川右千夫, 小幡邦彦, 桑名俊一
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      20080300
  • [Presentation] Effect of a new sedative, JM-1232(-) on central respiratory activity in neonatal rats.2008

    • Author(s)
      Kuribayashi J, Kuwana S, Hosokawa Y, Hatori E, Takeda J.
    • Organizer
      Annual meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orland, USA
    • Year and Date
      20080000
  • [Presentation] 新生ラット摘出脳幹-脊髄標本の呼吸関連ニューロンにおけるTASKの分布の検討2007

    • Author(s)
      原田尚子, 小山田吉孝, 桑名俊一, 中谷理恵, 刀川夏詩子, 本田岳夫, 仲嶋一範, 石坂彰敏
    • Organizer
      第47回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      20070500
  • [Presentation] Neural mechanisms of sevoflurane-induced central respiratory depression in neonatal rats.2007

    • Author(s)
      Kuribayashi J, Kuwana S, Sakuraba S., Hosokawa Y, Takeda J.
    • Organizer
      American Society of Anesthesiologist Annual Meeting 2007
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-10-13
  • [Book] からだと酸素の事典2009

    • Author(s)
      酸素ダイナミクス研究会編, 田村守,桑名俊一, 他117名著
    • Publisher
      朝倉書店

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Published: 2011-06-18   Modified: 2016-04-21  

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