2011 Fiscal Year Final Research Report
Strategy for producing a variety type of neurons by regulating spatial and temporal identities of neural stem cells
| Project/Area Number |
19670002
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Center of Neurology and Psychiatry (2008-2011)
Kyoto University (2007) |
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Principal Investigator |
HOSHINO Mikio 独立行政法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, 部長 (70301273)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 神経発生 / 分化 / 異常 |
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| Research Abstract |
We clarified that two bHLH transcription factors(TFs), Math1 and Ptf1a, are involved in specifying the spatial identities of neural stem cells in the cerebellar primordium. We also found similar roles for these TFs in the hindbrain. Neural stem cells in the Ptf1a-expressing ventricular zone change their temporal identity ; while they produce Purkinje cells at early stages, they become to generate Pax2 positive interneurons at late stages. We clarified that two TFs, Olig2 and Gsh1, are involved in regulating temporal identity of neural stem cells in the cerebellar ventricular zone.
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[Journal Article] Origin of the brush cell lineage in the mouse intestinal epithelium2012
Author(s)
Bjerknes M, Khandanpour C, Moroy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martin MG, Chen H
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Journal Title
Dev. Biol
Volume: 362
Pages: 194-218
DOI
Peer Reviewed
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[Journal Article] Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh12009
Author(s)
Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M
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Journal Title
Development
Volume: 136
Pages: 2049-2058
DOI
Peer Reviewed
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[Journal Article] Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening2009
Author(s)
Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, OkazawaH, Nabeshima Y
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Journal Title
PloS ONE
Volume: 4
Pages: e4466
DOI
Peer Reviewed
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[Journal Article] Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes mellitus in mice2008
Author(s)
Fukuda A, Kawaguchi Y, Furuyama F, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CVE, Hoshino M, Chiba T, Uemoto S
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Journal Title
Diabetes
Volume: 57
Pages: 2415-2429
DOI
Peer Reviewed
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[Journal Article] Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent proteini kinase CLICK-III/CaMKIγ2007
Author(s)
Takemoto-Kimura S, Ishihara-Ageta N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H, Bito H
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Journal Title
Neuron
Volume: 54
Pages: 755-770
DOI
Peer Reviewed
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[Journal Article] Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse
Author(s)
Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, Miki H
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Journal Title
Science Signaling
Volume: 4(179)
DOI
Peer Reviewed
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