Involvement of the frontal cortex, basal ganglia, and cerebellum in voluntary movement

2011 Fiscal Year Final Research Report

• Project/Area Number: 19670004
• Research Category: Grant-in-Aid for Young Scientists (S)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: 財団法人東京都医学総合研究所 (2011); Tamagawa University (2007-2010)
• Principal Investigator: HOSHI Eiji 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (50407681)
• Project Period (FY): 2007 – 2011
• Keywords: 神経解剖学 / 神経生理学 / 運動前野 / 前頭前野 / 一次運動野

Research Abstract

In one series of studies, anatomical organization linking the frontal cortex, the basal ganglia, and the cerebellum was analyzed systematically. In another series, functional roles played by each structure were examined by comparing patterns of neural activity recorded from subjects performing behavioral tasks. The results obtained by the two series of experimental analyses have revealed new aspects of neuronal mechanisms underlying the voluntary movement.

Research Products

• [Journal Article] Development of multidimensional representations of task phases in the lateral prefrontal cortex (2011)
  • Author(s): Saga, Y., Iba, M., Tanji, J., and Hoshi, E.
  • Journal Title: J. Neurosci Volume: 31 Pages: 10648-65
  • DOI: DOI:10.1523/JNEUROSCI.0988-11.2011
  • Peer Reviewed
• [Journal Article] Origins of multisynaptic projections from the basal ganglia to rostrocaudally distinct sectors of the dorsal premotor area in macaques (2011)
  • Author(s): Saga, Y., Hirata, Y., Takahara, D., Inoue, K., Miyachi, S., Nambu, A., Tanji, J., Takada, M., and Hoshi, E.
  • Journal Title: Eur. J. Neurosci Volume: 33 Pages: 285-97
  • DOI: DOI:10.1111/j.1460-9568.2010.07492.x.
  • Peer Reviewed
• [Journal Article] Neural mechanisms underlying the integration of perception and action (2011)
  • Author(s): Hoshi, E., Nakayama, Y., Yamagata, T., Saga, Y., Hashimoto, M., Arimura, N. and Tanji, J.
  • Journal Title: Brain and Nerve Volume: 63 Pages: 59-68
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21228449
  • Peer Reviewed
• [Journal Article] Motor and nonmotor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques (2010)
  • Author(s): Hashimoto, M., Takahara, D., Hirata, Y., Inoue, K., Miyachi, S., Nambu, A., Tanji, J., Takada, M., and Hoshi, E.
  • Journal Title: Eur. J. Neurosci Volume: 31 Pages: 1402-13
  • DOI: DOI:10.1111/j.1460-9568.2010.07151.x
  • Peer Reviewed
• [Journal Article] Processing of visual signals for direct specification of motor targets and for conceptual representation of action targets in the dorsal and ventral premotor cortex (2009)
  • Author(s): Yamagata, T., Nakayama, Y., Tanji, J., and Hoshi, E.
  • Journal Title: J. Neurophysiol Volume: 102 Pages: 3280-94
  • DOI: DOI:10.1152/jn.00452.2009
  • Peer Reviewed
• [Journal Article] On Somatotopical Organization of Cortical Motor Areas (2009)
  • Author(s): Tanji, J., Nakayama, Y., Yamagata, T., and Hoshi, E.
  • Journal Title: Brain and Nerve Volume: 61 Pages: 1363-71
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20034303
  • Peer Reviewed
• [Journal Article] Transformation of a virtual action plan into a motor plan in the premotor cortex (2008)
  • Author(s): Nakayama, Y., Yamagata, T., Tanji, J., and Hoshi, E.
  • Journal Title: J. Neurosci Volume: 28 Pages: 10287-97
  • DOI: DOI:10.1523/JNEUROSCI.2372-08.2008
  • Peer Reviewed
• [Journal Article] Role of the lateral prefrontal cortex in executive behavioral control (2008)
  • Author(s): Tanji, J. and Hoshi, E.
  • Journal Title: Physiol. Rev Volume: 88 Pages: 37-57
  • DOI: DOI:10.1152/physrev.00014.2007
  • Peer Reviewed
• [Presentation] A comparison of neuronal activity of globus pallidus and premotor cortex in retrieving a virtual action plan instructed by a visual object and in developing a physical motor plan (2011)
  • Author(s): Arimura, N., et al.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] Comparing the involvement of the lateral prefrontal cortex(LPFC) and dorsal premotor cortex(PMd) in representing the virtual action plan and motor plan (2011)
  • Author(s): Yamagata, T., et al.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] Differential distribution of activities reflecting planning, preparation, and execution of action in six motor areas of the frontal lobe (2011)
  • Author(s): Nakayama, Y., et al.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Book] Premotor Areas : Medial. Encyclopedia of Neuroscience (2009)
  • Author(s): Tanji, J, Hoshi, E.
  • Total Pages: 925-933
• [Remarks]
  • URL: http://www.igakuken.or.jp/frontal-lobe/