2011 Fiscal Year Final Research Report
Elucidation for the role of heparan sulfate in neural crest cell differentiation and establishment of a new concept for glaucoma pathogenesis.
| Project/Area Number |
19679008
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | University of Fukui (2010-2011)
Kumamoto University (2007-2009) |
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Principal Investigator |
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| Project Period (FY) |
2007 – 2011
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| Keywords | 眼科学 |
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| Research Abstract |
The anomaly of the anterior chamber angle causes glaucoma. We elucidated the role of heparan sulfate in the anterior chamber angle development. The deficiency of heparan sulfate disturbs the differentiation of neural crest cells, which causes glaucoma in mice. We revealed that TGFβ_2 signaling in the differentiation of neural crest cells depends on the expression of heparan sulfate on the cell surface. We can inactivate fibroblasts by inhibiting the interaction between heparan sulfate and TGFβ_2, which improves the surgical outcome of filtration surgery in glaucoma animal models.
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Research Products
(27 results)
