Identification of a novel nutrient signal related on health and longevity : role in the prevention of common diseases.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19680030
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: TAKETANI Yutaka The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)
• Research Collaborator: SHUTO Emi 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; TANAKA Rieko 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; WATARI Eriko 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; KITAMURA Tomoyo 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; SHIOTA Asuka 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; TAN Vu van 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; UEBANSO Takashi 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; AMO Kikuko 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; TANIMURA Ayako 徳島大学, 大学院・栄養生命科学教育部, 大学院生
• Project Period (FY): 2007 – 2009
• Keywords: シグナル伝達 / リン / 血管内皮細胞 / 高リン血症 / 心血管疾患 / 慢性腎臓病 / 予防栄養学

Research Abstract

Nutrients and their metabolites are balanced within adequate levels to maintain normal physiological functions. Impairment of the balance of nutrient metabolism by unfavorable diet causes life-style related diseases such as diabetes, cardiovascular disease, etc. In this research, we investigated the role of nutrient signal, especially focused on "phosphate signal" that is closely related on aging and some life-style related diseases. Hyperphosphatemia caused by high phosphate intake can induce endothelial dysfunction through the phosphate signal, and it would be a risk factor for cardiovascular cliseaSe.

Research Products

• [Journal Article] Dietary phosphorus acutely impairs endothelial function. (2009)
  • Author(s): Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Arno K, Yamamoto H, Higashi Y, Nakaya Y, Takeda E.
  • Journal Title: J Am Soc Nephrol 20(7) Pages: 1504-1512
  • Peer Reviewed
• [Journal Article] Hypocaloric high protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways. (2009)
  • Author(s): Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Arno K, Harada N, Arai H, Yamamoto H, Takeda E.
  • Journal Title: Am J Physiol Endocrinol Metab 297(1) Pages: E76-84
  • Peer Reviewed
• [Journal Article] Stanniocalcin 2 is positively and negatively controlled by 1, 25(OH)(2)D(3) and PTH in renal proximal tubular cells. (2009)
  • Author(s): Takei Y, Yamamoto H, Masuda M, Sato T, Taketani Y, Takeda E.
  • Journal Title: J Mol Endoclinol 42 Pages: 261-268
  • Peer Reviewed
• [Journal Article] Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice. (2009)
  • Author(s): Yoshida M, Harada N, Yamamoto H, Taketani Y, Nakagawa T Yin Y, Hattori A, Zenitani T, Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, Hosaka T, Takahashi A, Yoshimoto K, Nakaya Y.
  • Journal Title: Biochim Biophys Acta 1791 Pages: 39-52
  • Peer Reviewed
• [Journal Article] Dose-dependent effects of barley cooked with white rice on postprandial glucose and desacyl ghrelin levels. (2009)
  • Author(s): Sakuma M, Yamanaka-Okumura H, Naniwa Y, Matsumoto D, Tsunernatsu M, Yamamoto H, Taketani Y, Takeda E.
  • Journal Title: J Clin Biochem Nutr 44 Pages: 151-159
  • Peer Reviewed
• [Journal Article] Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats. (2008)
  • Author(s): Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E.
  • Journal Title: J Med Invest 55 Pages: 183-195
  • Peer Reviewed
• [Journal Article] Naito and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses. (2008)
  • Author(s): Taniguchi A, Yamanaka-Okumura H, Nishida Y, Yamamoto H, Taketani Y, Takeda E.
  • Journal Title: Asia Pac J Clin Nutr 17 Pages: 663-668
  • Peer Reviewed
• [Journal Article] Parathyroid hormone dependent endocytosis of renal type Be Na/Pi cotransporter. (2007)
  • Author(s): Segawa H, Yamanaka S, Onitsuka A, Tomoe Y, Kuwahata M, Ito M, Taketani Y, Miyamoto KT.
  • Journal Title: Am J Physfol Renal Physiol 292(1) Pages: F395-F403
  • Peer Reviewed
• [Journal Article] Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men. (2007)
  • Author(s): Arai H, Mizuno A, Sakuma M, Fukaya M, Ivlatsuo K, Muto K, Sasaki H, Matsuura M, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E.
  • Journal Title: Metabolism 56(1) Pages: 115-121
  • Peer Reviewed
• [Journal Article] Advantage of low glycemie index and low phosphate diet on diabetic nephropathy and aging-related diseases. (2007)
  • Author(s): Taketani Y, Shuto E, Nishida Y, Tanaka R.
  • Journal Title: J Med Invest 54 Pages: 359-365
  • Peer Reviewed
• [Journal Article] Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts. (2007)
  • Author(s): Sawada N, Taketani Y, Amizuka N, Ichikawa M, Ogawa C, Nomoto K, Nashiki K, Sato K, Arai H, Isshiki M, Segawa H, Yamamoto H, Miyamoto K, Takeda E.
  • Journal Title: Bone 41(1) Pages: 52-58
  • Peer Reviewed
• [Journal Article] Effects of Prolonged High Phosphorus Diet on Phosphonis and Calcium Balance in Rats. (2007)
  • Author(s): Tani Y, Sato T, Yamanaka-Okumura H, Yamamoto H, Arai H, Sawada N, Genjida K, Taketani Y, Takeda E.
  • Journal Title: J Clin Biochem Nutr 40(3) Pages: 221-228
  • Peer Reviewed
• [Journal Article] Dietary Palatinose and Oleic Acid Ameliorates Disorders of Glucose and Lipid Metabolism in Zucker Fatty Rats. (2007)
  • Author(s): Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E.
  • Journal Title: J Nutt. 137(8) Pages: 1908-1915
  • Peer Reviewed
• [Journal Article] Mechanism of rapid-phase insulin response to elevation of portal glucose concentration. (2007)
  • Author(s): Fukaya M, Mizuno A, AraiH, Muto K, Uebanso T, Matsuo K, Yamamoto H, Taketani Y, Doi T, Takeda E.
  • Journal Title: Am J Physiol Endocrinel Metah 293(2) Pages: E515-E522
  • Peer Reviewed
• [Journal Article] Involvement of cell-surface ATP synthase in flow-induced ATP release by vascular endothelial cells. (2007)
  • Author(s): Yamamoto K, Shimizu N, Obi S, Kumagaya S, Taketani Y, Kamiya A, Ando J.
  • Journal Title: Am J Physiol Heart Circ Physiol 293(3) Pages: H1646-H1653
  • Peer Reviewed
• [Presentation] Sodium-dependent phosphate transporter and cardiovascular disease (2010)
  • Author(s): Yutaka Taketani
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山市
  • Year and Date: 20100328-20100330
• [Presentation] リン血症と心血管疾患:血管機能障害におけるリン摂取の問題 (2010)
  • Author(s): 竺谷豊高
  • Organizer: 腎臓病と栄養-代謝・食事フォーラム2010
  • Place of Presentation: 東京都
  • Year and Date: 2010-03-27
• [Presentation] Over-Intake of Dietary Phosphorus Accelerates Progression of Atherosclerotic Lesions in Apolipoprotein E Deficient (2009)
  • Author(s): Asuka Shiota, Yutaka Taketani, Ayako Tanimura, Hironori Yamamoto, Eiji Takeda
  • Organizer: Mice 42nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 20091027-20091101
• [Presentation] Excessive Dietary Phosphorus Acutely Impairs Endothelial Function in Healthy Men. (2009)
  • Author(s): Emi Shuto, Yutaka Taketani, Wakana Kusunose, Terumi Tanaka, Daisuke Eerie, Kikuko Amo, Hironori Yamamoto, Tohru Sakai, Eiji Takeda
  • Organizer: 42nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 20091027-20091101
• [Presentation] Fluctuation of Serum Phosphorus Levels Impairs Endothelial Function in Rats. (2009)
  • Author(s): Eriko Watari, Tormoyo Kitamura, Yutaka Taketani, Ayako Tanimura, Asuka Shiota, Enai Shuto, Tan Vu Van, Hironori Yamamoto, Eiji Takeda
  • Organizer: 42nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 20091027-20091101
• [Presentation] Hyperphosphatemia Mediates Oxidative Stress in Bovine Aortic Endothelial Cells (2009)
  • Author(s): Shuto E, Taketani Y. Tanaka R, Tanimura A, Isshiki M, Harada N, Yamamoto H, Takeda E.
  • Organizer: 29th Annual Meeting of American Scociety for Bone and Mineral Research
  • Place of Presentation: Honolulu, Hawai, USA
  • Year and Date: 20090916-20090919
• [Presentation] Dual Role of Type III Sodium-Dependent Phosphate Transporter in the Pathogenesis of Arteriosclerosis Caused by Hyperphosphatemia. (2009)
  • Author(s): Takatani Y, Shuto E, Shiota A, Tanimura A, Watari E, Kitamura Yamamoto H, Takeda E.
  • Organizer: 31st. Annual Meeting of American Society of Bone and Mineral Research
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production. (2009)
  • Author(s): Taketani Y, Shuto E, Shiota A, Watari E, Kitamura T, HaradaN, Nakaya Y, Miyamoto K, Takeda E.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: 京都市
  • Year and Date: 20090727-20090801
• [Presentation] Sodium-dependent phosphate transporter in the cardiovascular dysfunction. (2009)
  • Author(s): Taketani Y, Shuto E, Tanaka R, Isshiki M, Miyamoto K, Takeda E.
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 20090316-20090318
• [Presentation] Effects of Postprandial Hyperphosphatemia on Endothelial Function. (2008)
  • Author(s): Yutaka Taketani, Emi Shuto, Rieko Tanaka, Masashi Isshiki, Kikuko Amo, Hironori Yamamoto, Ken-ichi Miyamoto, Eiji Takeda
  • Organizer: 41nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia, Pennsylvania, USA
  • Year and Date: 20081104-20081109
• [Presentation] Mutation of Type IIc Na+-Dependent Phosphate Cotransporter (NaPPi-IIc) and Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH) (2008)
  • Author(s): Mikiko Ito, Aya Sakurai, Akiko Ohi, Keiji Hayashi, Takashi Nishiyama, Natsumi Kangawa, Sakiko Sugino, Sawako Tatsumi, Hiroko Segawa, Yutaka Taketani, Ken-ichi Miyamoto
  • Organizer: 41nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia, Pennsylvania, USA
  • Year and Date: 20081104-20081109
• [Presentation] Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction. (2008)
  • Author(s): Shuto E, Taketani Y, Tanaka R, Tanimura A, Uebanso T, Isshiki M, Harada N, Yamamoto H, Nakaya Y, Takeda E.
  • Organizer: 30th Annual Meeting of American Scociety for Bone and Mineral Research
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080916-20080919
• [Book] リントランスポ-タ-と疾患」最新トランスポーター研究2009(編集1杉山雄一、金井好克) (2009)
  • Author(s): 宮本賢一, 瀬川博子、伊藤美紀子、辰巳佐和子
  • Total Pages: 243-247
  • Publisher: 株式会社メディカルドゥ
• [Book] 「栄養素トランスポーターの分子制御とホルモン代謝:リン酸トランスポーターをめぐる話題」トランスポーター科学最前線(総編集:辻彰) (2008)
  • Author(s): 宮本賢一、竹谷豊、桑波田雅士、伊藤美紀子、瀬川博子、辰巳佐和子
  • Total Pages: 245-262
  • Publisher: 京都廣川書店