2009 Fiscal Year Final Research Report
Research for the effects of toluene exposure on the development and sexual differentiation of the brain
| Project/Area Number |
19681006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
TSUKAHARA Shinji National Institute for Environmental Studies, 大学院・理工学研究科, 准教授 (90318824)
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| Project Period (FY) |
2007 – 2009
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| Keywords | トルエン / 脳の性分化 / テストステロン / 性的二型核 / アポトーシス |
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| Research Abstract |
We recently pay attention to the risk of the adverse effects of environmental chemical exposure on child health. This study was aimed to determine the effects of developmental exposure to toluene, a volatile organic compound widely used as an industrial solvent, on the sexual differentiation of the brain. As the results, it was found that exposure to toluene during developing period decreased blood testosterone levels of fetal male rats and the volume of the SDN-POA, a sexually dimorphic nucleus, of male rats in adulthood.
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