2009 Fiscal Year Final Research Report
Rational Design of Unnatural Substrates for Expanded Ribosomal Synthesis of Sequence-Regulated Compounds
| Project/Area Number |
19685016
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
SANDO Shinsuke Kyoto University, 稲盛フロンティア研究センター, 教授 (20346084)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 蛋白質 / リボソーム / 配列制御型合成 |
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| Research Abstract |
The cellular translation system is a sophisticated molecular system that can polymerize substrates (amino acids) in a highly sequence-programmed manner to produce biomolecules (proteins). In this research, we challenged expansion of substrates that can be used for ribosomal-synthesis of a variety of artificial compounds, especially by chemical approach, and developed a new method for efficient use of such unnatural substrates.
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