2010 Fiscal Year Final Research Report
Study for target molecules of poIyphenoIs to evaluate their functions and safety.
| Project/Area Number |
19688007
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAWAI Yoshichika The University of Tokushima, 大学院・ヘルスバイオサエン研究部, 助教 (50380027)
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| Project Period (FY) |
2007 – 2010
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| Keywords | ポリフェノール / 酸化ストレス / マクロファージ / 動脈硬化症 / 炎症 / βグルクロニダーゼ / オートファジー |
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| Research Abstract |
To investigate the molecular mechanism for the functions and safety of polyphenols and to identify their molecular targets, we developed novel monoclonal antibodies that specifically recognize quercetin or epicatechin gallate. Using these antibodies, we have identified macrophage cells in human aorta as the specific target of these polyphenols.
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[Journal Article] Different profiles of quercetin metabolites in rat plasma : comparison of two administration methods.2009
Author(s)
Kawai, Y., Saito, S., Nishikawa, T., Ishisaka, A., Murota, K., Terao, J.
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Journal Title
Biosci. Biotechnol.Biochem. 73
Pages: 517-523
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[Journal Article] Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites.2008
Author(s)
Shiba, Y., Kinoshita, T., Chuman, H., Taketani, Y., Takeda, E., Kato, Y., Naito, M., Kawabata, K., Ishisaka, A., Terao, J., Kawai, Y.
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Journal Title
Chem.Res. Toxicol. 21
Pages: 1600-1609
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[Journal Article] Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids.2008
Author(s)
Kawai, Y., Nishikawa, T., Shiba, Y., Saito, S., Murota, K., Shibata, N., Kobayashi, M., Kanayama, M., Uchida, K., Terao, J.
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Journal Title
J.Biol.Chem. 283
Pages: 9424-9434
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[Journal Article] Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage.2008
Author(s)
Kawai, Y., Matsui, Y., Kondo, H., Morinaga, H., Uchida, K., Miyoshi, N., Nakamura, Y., Osawa, T.
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Journal Title
Chem.Res. Toxicol. 21
Pages: 1407-1414
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[Journal Article] Immunochemical detection of flavonoid glycosides: development, specificity, and application of novel monoclonal antibodies.2008
Author(s)
Kawai, Y., Ishisaka, A., Saito, S., Uchida, K., Shibata, N., Kobayashi, M., Fukuchi, Y., Naito, M., Terao, J.
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Journal Title
Arch.Biochem.Biophys. 476
Pages: 124-132
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