2010 Fiscal Year Final Research Report
Regulation of Nuclear Receptor Functions
| Project/Area Number |
19689004
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Ochanomizu University |
|---|
Principal Investigator |
TANATANI Aya Ochanomizu University, 大学院・人間文化創成科学研究科, 准教授 (40361654)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 核内受容体 / アンドロゲン / プロゲステロン / ビタミンD / アゴニスト / アンタゴニスト / 蛍光性リガンド |
|---|
| Research Abstract |
Nuclear receptors are ligand-inducible transcription factors, and regulate various biological phenomena, such as cell differentiation and proliferation, metabolism, and homeostasis. Nuclear receptors have been regarded as significant molecular targets for development of drugs for cancers, cardiovascular diseases, autoimmune diseases, and neurodegenerating diseases. In this study, I developed novel ligands for some nuclear receptors that have unique structures and biological functions.
|
Research Products
(42 results)
-
[Journal Article] Calix[3]amide-based anion receptors : High affinity for fluoride ions and twisted binding model.2011
Author(s)
Katagiri, K., Furuyama, T., Masu, H., Kato, T., Matsumura, M., Uchiyama, M., Tanatani, A., Tominaga, M., Kagechika, H., Yamaguchi, K., Azumaya, I.
-
Journal Title
Suplamolecular Chemistry 23
Pages: 125-130
Peer Reviewed
-
[Journal Article] Cyclic-tri(N-methyl-meta-benzamide)s : Substituent Effect on the Bowl-shaped Conformation in the Crystal and Solution States.2011
Author(s)
Kakuta, H., Azumaya, I., Masu, H., Matsumura, M., Yamaguchi, K., Kagechika, H., Tanatani, A.
-
Journal Title
Tetrahedron 66
Pages: 8254-8260
Peer Reviewed
-
[Journal Article] Identification of Absolute Helical Structures of Aromatic Multilayered Oligo(m-phenylurea)s in Solution.2009
Author(s)
Kudo, M., Hanashima, T., Muranaka, A., Sato, H., Uchiyama, M., Azumaya, I., Hirano, T., Kagechika, H., Tanatani, A.
-
Journal Title
J.Org.Chem. 74
Pages: 8154-8163
Peer Reviewed
-
-
[Journal Article] Fluorescent visualization of the conformational change of aromatic amide or urea induced by N-methylation.2009
Author(s)
Hirano, T., Osaki, T., Fujii, S., Komatsu, D., Azumay, I.; Tanatani, A., Kagechika, H.
-
Journal Title
Tetrahedron Lett. 50
Pages: 488-491
Peer Reviewed
-
-
[Journal Article] Redox-Induced Conformational Alteration of N2007
Author(s)
Okamoto, I., Yamasaki, R., Sawamura, M., Kato, T., Nagayama, N., Takeya, T., Tamura, O., Masu, H., Azumaya, I., Yamaguchi, K., Kagechika, H., Tanatani, A.
-
Journal Title
N-Diaryamides.Org.Lett. 9
Pages: 5545-5547
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Novel VDR agonists bearing carborane : Synthesis, biological activity and VDR binding structure.2008
Author(s)
Masuno, H.; Fujii, S.; Kano, A .;Hirano, T.; Kawachi, E.; Tanatani, A.; Nakabayashi, M.; Ikura, T.; Ito, N.; Shimizu, M.; Kagechika, H.
Organizer
CBI Annual Meeting
Place of Presentation
東京
Year and Date
2008-10-22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
