2009 Fiscal Year Final Research Report
Utilization of spontaneous melanoma mice for finding biomarkers
| Project/Area Number |
19700371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Chubu University |
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Principal Investigator |
KAWAMOTO Yoshiyuki Chubu University, 生命健康科学部, 准教授 (10410664)
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| Project Period (FY) |
2007 – 2009
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| Keywords | バイオマーカー / メラノーマ / RET / ケモカイン |
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| Research Abstract |
RET-transgenic mice, which develop malignant melanoma, are useful for finding biomarkers which express in the serum or urine correlated with tumor progression and/or metastasis. We found that chemokin (C-X-C motif) ligand, CXCL10 and CXCL16 are significantly increased in serum of RET-transgenic mice which has malignant tumor. Our findings suggest that these proteins can be candidates for new biomarkers of melanoma.
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[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
Author(s)
Kato M, Takeda K, Hossain K, Thang ND, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
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Journal Title
J Cell Biochem. 110(2)
Pages: 399-407
Peer Reviewed
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[Journal Article] 1, 4-butanediyl-bismethanethiosulfonate (BMTS) induces apoptosis through reactive oxygen species-mediated mechanism.2009
Author(s)
Hossain K, Kawamoto Y, Hamada M, Akh, AA, Yanagishita T, Hoque MA, Tsuboi H, Kato M, Nakashima I.
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Journal Title
J Cell Biochem. 108(5)
Pages: 1059-65
Peer Reviewed
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