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2010 Fiscal Year Final Research Report

Functional analysis and comprehensive isolation of meiosis-specific genes in Schizosaccharomyces pombe.

Research Project

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Project/Area Number 19710164
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 基礎ゲノム科学
Research InstitutionOsaka University

Principal Investigator

OKUZAKI Daisuke  Osaka University, 微生物病研究所, 助教 (00346131)

Project Period (FY) 2007 – 2010
Keywords分裂酵母 / 減数分裂 / 生殖・分化 / 細胞周期 / リン酸化
Research Abstract

Germ cell research in humans and higher organisms, but is essential and urgent task facing the ethical and technical issues. To overcome this problem continues to study more than ten years ago with a model organism for the study of meiosis in fission yeast reproduction. Isolation and functional analysis performed comprehensive transcription of genes specifically induced by meiosis-based comprehensive analysis of genome information and proprietary technology that also exist in mammalian genes aimed at understanding the mechanism of mammalian reproduction identified by analyzing a large number.

  • Research Products

    (29 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (11 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express borna disease virus phosphoprotein.2011

    • Author(s)
      Honda T, Fujino K, Okuzaki D, Ohtaki N, Matsumoto Y, Horie M, Daito T, Itoh M, Tomonaga K.
    • Journal Title

      J Virol. 85(9)

      Pages: 4567-4571

    • Peer Reviewed
  • [Journal Article] MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.Oncogene.2011

    • Author(s)
      Oneyama C, Ikeda J, Okuzaki D, Suzuki K, Kanou T, Shintani Y, Morii E, Okumura M, Aozasa K, Okada M.
    • Journal Title

      2011 Oncogene advance online publication 63

      Pages: doi:10.1038/onc.

    • Peer Reviewed
  • [Journal Article] The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.2010

    • Author(s)
      Tougan T, Kasama T, Ohtaka A, Okuzaki D, Saito TT, Russell P, Nojima H.
    • Journal Title

      Cell Cycle. 1;9(23)

      Pages: 4688-4702

    • Peer Reviewed
  • [Journal Article] GenopalTM : a novel hollow fibre array for focused microarray analysis2010

    • Author(s)
      Okuzaki D, Fukushima T, Tougan T, Ishii T, Kobayashi S, Yoshizaki K, Akita T, Nojima H.
    • Journal Title

      DNA Res. 17(6)

      Pages: 369-379

    • Peer Reviewed
  • [Journal Article] Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.2010

    • Author(s)
      Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H.
    • Journal Title

      Curr Biol. 9;20(21)

      Pages: 1945-1952

    • Peer Reviewed
  • [Journal Article] Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe.2010

    • Author(s)
      Okuzaki D, Kasama T, Hirata A, Ohtaka A, Kakegawa R, Nojima H.
    • Journal Title

      Cell Cycle. 15;9(18)

      Pages: 3751-3760

  • [Journal Article] Mug28, a meiosis-specific protein of Schizosaccharomyces pombe, regulates spore wall formation.2010

    • Author(s)
      Shigehisa A, Okuzaki D, Kasama T, Tohda H, Hirata A, Nojima H.
    • Journal Title

      Mol Biol Cell. 15;21(12)

      Pages: 1955-1967

    • Peer Reviewed
  • [Journal Article] Microarray analysis of tonsils in immunoglobulin A nephropathy patients.2010

    • Author(s)
      Iio K, Nagasawa Y, Iwatani H, Yamamoto R, Horii A, Okuzaki D, Furumatsu Y, Inohara H, Nojima H, Imai E, Isaka Y, Rakugi H.
    • Journal Title

      Biochem Biophys Res Commun. 19;393(4)

      Pages: :565-570

    • Peer Reviewed
  • [Journal Article] Chum-RNA allows preparation of a high-quality cDNA library from a single-cell quantity of mRNA without PCR amplification.2008

    • Author(s)
      Tougan T, Okuzaki D, Nojima H.
    • Journal Title

      Nucleic Acids Res. 36(15)

      Pages: 92

    • Peer Reviewed
  • [Journal Article] Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients.2008

    • Author(s)
      Kobayashi S, Ito A, Okuzaki D, Onda H, Yabuta N, Nagamori I, Suzuki K, Hashimoto H, Nojima H.
    • Journal Title

      DNA Res. 15(4)

      Pages: 253-265

    • Peer Reviewed
  • [Journal Article] Mug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation.2008

    • Author(s)
      Ohtaka A, Okuzaki D, Nojima H.
    • Journal Title

      J Cell Sci. 1;121(Pt 9)

      Pages: 1547-1558

    • Peer Reviewed
  • [Journal Article] Focused microarray analysis of peripheral mononuclear blood cells from Churg-Strauss syndrome patients.2008

    • Author(s)
      Tougan T, Onda H, Okuzaki D, Kobayashi S, Hashimoto H, Nojima H.
    • Journal Title

      DNA Res. 30;15(2)

      Pages: 103-114

    • Peer Reviewed
  • [Journal Article] Lats2 is an essential mitotic regulator required for the coordination of cell division.2007

    • Author(s)
      Yabuta N, Okada N, Ito A, Hosomi T, Nishihara S, Sasayama Y, Fujimori A, Okuzaki D, Zhao H, Ikawa M, Okabe M, Nojima H.
    • Journal Title

      J Biol Chem. 29;282(26)

      Pages: 19259-19271

    • Peer Reviewed
  • [Journal Article] Mcp4, a meiotic coiled-coil protein, plays a role in F-actin positioning during Schizosaccharomyces pombe meiosis.2007

    • Author(s)
      Ohtaka A, Okuzaki D, Saito TT, Nojima H.
    • Journal Title

      Eukaryot Cell. 6(6)

      Pages: 971-983

    • Peer Reviewed
  • [Journal Article] Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe.2007

    • Author(s)
      Ohtaka A, Saito TT, Okuzaki D, Nojima H.
    • Journal Title

      Cell Div. 18;2

      Pages: 14

    • Peer Reviewed
  • [Presentation] Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe2010

    • Author(s)
      奥崎大介
    • Organizer
      第33回日本分子生物学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
  • [Presentation] A novel Diagnostic markers for Takayasu Arteritis obtained by GenopalTM focused microarray based on Spearman rank correlation2010

    • Author(s)
      奥崎大介
    • Organizer
      第33回日本分子生物学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
  • [Presentation] 分裂酵母RNA結合タンパク質Mug28による配偶子形成の制御機構2010

    • Author(s)
      奥崎大介
    • Organizer
      第43回酵母遺伝学フォーラム研究報告会
    • Place of Presentation
      奈良
    • Year and Date
      2010-09-10
  • [Presentation] A novel Diagnostic markers for Takayasu Arteritis obtained by Genopal focused microarray based on Spearman rank correlation2010

    • Author(s)
      奥崎大介
    • Organizer
      第10回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2010-09-08
  • [Presentation] 細胞生物学者の視点でみるマイクロアレイと次世代シーケンス2010

    • Author(s)
      奥崎大介
    • Organizer
      第62回日本細胞生物学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-05-19
  • [Presentation] MUG28, A MEIOSIS-SPECIFIC PROTEIN OF SCHIZOSACCHAROMYCES POMBE, REGULATES SPORE WALL FORMATION2009

    • Author(s)
      奥崎大介
    • Organizer
      The 5th International Fission Yeast Meeting
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都)
    • Year and Date
      2009-10-29
  • [Presentation] DETECTシステムの開発2009

    • Author(s)
      奥崎大介
    • Organizer
      第82回生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2009-10-21
  • [Presentation] GenopalTM ; a novel device for focused microarray equipped with hollow fiber array2009

    • Author(s)
      奥崎大介
    • Organizer
      第9回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Year and Date
      2009-09-10
  • [Presentation] Fission yeast Arp1 facilitates meiotic nuclear oscillation via Dhc1 and Mcp52008

    • Author(s)
      奥崎大介
    • Organizer
      The 2008 Yeast Genetics and Molecular Biology Meeting
    • Place of Presentation
      カナダ・トロント大学
    • Year and Date
      2008-07-23
  • [Presentation] 分裂酵母の減数分裂期特異的コイルドコイルタンパク質:Mcp4の機能解析2007

    • Author(s)
      奥崎大介
    • Organizer
      第40回酵母遺伝学フォーラム
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      20070911-20070913
  • [Presentation] 分裂酵母の減数分裂特異的カイネース:Mug27/Lts1の機能解析2007

    • Author(s)
      奥崎大介
    • Organizer
      第30回日本分子生物学会年会、BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
  • [Remarks] ホームページ等

    • URL

      http://www.biken.osaka-u.ac.jp/lab/molgenet/

  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/DNA_chip/

  • [Patent(Industrial Property Rights)] 白血球タンパク質の回収方法および回収装置2009

    • Inventor(s)
      野島博、藪田紀一、奥崎大介
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特許,K2009-0042
    • Filing Date
      2009-10-26

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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