2010 Fiscal Year Final Research Report
Identification of Autotomy-Promoting Factor from Sea stars and Molecular mechanism of Autotomy
| Project/Area Number |
19710190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
UKAI Kazuyo Tohoku Pharmaceutical University, 薬学部, 助教 (60433512)
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| Project Period (FY) |
2007 – 2010
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| Keywords | マヒトデ / Asterias amurensis / 自切 / 自切誘起因子 / APF / ニコチンアミド / N-メチルキノリン酸 / NMDA受容体 |
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| Research Abstract |
Japanese Asterias amurensis is known to have this ability of autotomy. The body fluids of scalded A.amurensis induced an arm autotomy of the intact A.amurensis by intracoelomic injection in an arm. A mixture of nicotinamide and N-methylquinolinic acid (NMQA) were assigned in this fraction as the inducers of autotomy. NMQA has been revealed to be a substrate of NMDA glutamate receptor.
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