2009 Fiscal Year Final Research Report
Studies of molecular mechanisms in satellite cell self-renewal
| Project/Area Number |
19770189
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAGATA Yosuke The University of Tokyo, 教養学部, 特任助教 (50401211)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 細胞・組織 / 移植・再生医療 / 再生医学 / 発生・分化 / シグナル伝達 / 筋衛星細胞 / 自己複製 |
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| Research Abstract |
Skeletal muscle stem cells, usually called satellite cells, play central roles in skeletal muscle repair and regeneration. The self-renewal of satellite cells supports a remarkable regenerative potential of skeletal muscle. In this research, it was demonstrated that formation of reserve cells, which are quiescent and undifferentiated C2C12 myogenic cells, were controlled by Grb2-Sos-Ras mediated signaling pathways, suggesting that skeletal muscle satellite cells are maintained as a result of quiescence of activated satellite cells via those signaling pathways.
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