2009 Fiscal Year Final Research Report
Development of the antibody drug for prevention and treatment against alveolar echinococcosis
| Project/Area Number |
19780228
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido Institute of Public Health |
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Principal Investigator |
GOTO Akiko Hokkaido Institute of Public Health, 感染症センター生物科学部, 研究職員 (60414322)
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| Research Collaborator |
YAMANO Kimiaki 北海道立衛生研究所, 感染症センター生物科学部, 感染病理科長 (40435566)
YAGI Kinpei 北海道立衛生研究所, 感染症センター生物科学部, 主任研究員 (70414323)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 人獣共通感染症 / 多包性エキノコックス症 / 抗体医薬 |
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| Research Abstract |
Alveolar echinococcosis, which is caused by the larva of E. multilocularis (Em), is a life-threatening zoonotic parasitosis in humans. To develop the diagnosis and antibody drug for treatment against alveolar echinococcosis, I tried to construct some recombinant monoclonal antibodies from Em-infected mouse by using molecular biological methods. In result, four recombinant monoclonal antibodies reacting with Em antigen were constructed.
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