2009 Fiscal Year Final Research Report

The defensive mechanisms mediated by Toll-like receptors in canine uterus

Research Project

Project/Area Number	19780233
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Clinical veterinary science
Research Institution	Osaka Prefecture University
Principal Investigator	KIDA Kayoko Osaka Prefecture University, 生命環境科学研究科, 助教 (50405362)
Project Period (FY)	2007 – 2009
Keywords	Toll-likeレセプター / 感染防御 / イヌ / 子宮 / 発情周期
Research Abstract	The gene expression of Toll-like receptors (TLRs), that recognize the pathogen-associated molecular patterns (PAMP) and induce immune and inflammatory responses, and their signal pathway molecules were investigated in the canine endometrium. During estrous cycle, they didn't have most changes. However, when the endometrium was stimulated by PAMP, IL-6 and IL-8 mRNA (a kind of inflammatory cytokines) tended to more increase at estrus than at diestrus. It is possible that the immune and inflammatory responses induced by the stimulation of bacterial pathogen may change during the estrous cycle although TLR and their signal pathway molecules gene expression don't change.