2010 Fiscal Year Final Research Report
Development on new methodology for optical resolution using plant glycosyltransferases and its pharmacological exploitation
| Project/Area Number |
19790018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Oita University |
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Principal Investigator |
SHIMODA Kei Oita University, 医学部, 准教授 (40284153)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 有機合成化学 |
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| Research Abstract |
A plant xylosyltransferase was isolated from cultured plant cells by chromatographies using ion-exchange column, affinity column, and size excluding column. The new enzymatic resolution of (RS)-1-phenylalkyl β-D-glucosides has been achieved by stereoselective xylosylation with the enzyme to give (R)-1-phenylalkyl β-primeverosides and unreacted (S)-1-phenylalkyl β-D-glucosides with high diastereoselectivity.
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Research Products
(18 results)
